Cilostazol Reduces Periprocedural Hemodynamic Depression in Carotid Artery Stenting
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概要
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The clinical effects of two different types of antiplatelet drugs, cilostazol and thienopyridine drugs, were compared in patients treated by carotid artery stenting (CAS). Two hundred patients scheduled for CAS were randomized to either cilostazol or a thienopyridine drug (ticlopidine or clopidogrel). The study was conducted in open-label design. Aspirin was also given to all patients. All episodes of periprocedural hemodynamic instability (bradycardia, hypotension) were recorded together with all instances of stroke, cardiac morbidity, and death within 30 days of the procedure. Angiographic follow-up studies were conducted about 6 months after CAS. Finally, 197 patients were enrolled in this study; 97 were treated with cilostazol (cilostazol group) and 100 with a thienopyridine drug (thienopyridine group). In the 30-day follow-up period, the incidence of stroke, cardiac adverse effects, and death was not significantly different between the 2 groups (cilostazol group 7.2%, thienopyridine group 11.0%; p = 0.85). The incidence of intra- and postprocedural bradycardia was significantly lower in the cilostazol group (cilostazol group 18.6% and 2.1%, thienopyridine group 40.0% and 18.0%, respectively; p < 0.01). Although the incidence of intraprocedural hypotension did not significantly differ between the 2 groups, postprocedural hypotension was significantly lower in the cilostazol group (16.5% vs. 34.0%, p < 0.01). In-stent restenosis on follow-up angiograms was lower in the cilostazol group but not significantly (0% vs. 4.4%, p = 0.12). This small open-label study shows that cilostazol may reduce periprocedural bradycardia and hypotension compared with thienopyridine drugs in patients treated by CAS.
著者
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Etou Housei
Department Of Neurosurgery Fukuoka University Chikushi Hospital
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Narita Sumito
Department Of Cardiology Saiseikai Futsukaichi Hospital
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Aikawa Hiroshi
Department Of Environmental Health Tokai University School Of Medicine
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Yoshida Hidenori
Department Of Health Sciences Niigata University School Of Medicine
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Matsumoto Yoshihisa
Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa
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Inoue Ritsurou
Department Of Neurosurgery Fukuoka University Chikushi Hospital
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Sakamoto Kimiya
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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Nii Kouhei
Department of Neurosurgery, Fukuoka Kieikai Hospital
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Tsutsumi Masanori
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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Kazekawa Kiyoshi
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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KURESHIMA Makoto
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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NII Kouhei
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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INOUE Ritsurou
Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital
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