The effects of lesions in the nucleus basalis of Meynert and physostigmine on rat frontal cortex acetylcholine level
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概要
- 論文の詳細を見る
To clarify the relationship between acetylcholine (ACh) level in the frontal cortex and the area of lesion in the nucleus basalis of Meynert (nbM), we used ibotenic acid to bilaterally lesion the substantia innominata (SI), including the nbM, in rats and measured extracellular ACh by microdialysis. Baseline level of ACh (ACh-baseline) averaged 0.14±0.07 ng/40μl/20 min (n=13) in the steady state. We also measured the size of the lesioned areas in the SI (nbM-lesion) by using a computed image analysis system. Both ACh level and nbM-lesion varied widely among animals. The bilateral nbM-lesion averaged 28±30% (n=13). The correlation coefficient between ACh-baseline and bilateral nbM-lesion was -0.871 (p<0.01). After intraperitoneal injection of physostigmine, maximum ACh levels increased to 0.18±0.06 ng/40μl/20 min, and ΔACh (ACh-max/ACh-baseline) averaged 132±19% (n=8). There was no apparent correlation between ΔACh and bilateral nbM-lesion. These results show that the size of lesioned area in the bilateral SI was strongly correlated with the baseline ACh level in the frontal cortex, and indicate that the nbM is the major functional source of ACh in the frontal cortex. Our results also suggests that physostigmine possibly affects not only spared nbM-originated cholinergic fibers but also non-nbM-originated cholinergic fibers in the rat with the bilateral nbM lesion.
- 東海大学の論文
著者
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Aikawa Hiroshi
Departments of Neurosurgery, Chikushi Hospital, Fukuoka University
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Kato Hirotaka
Department of Mechanical Engineering, Fukui National College of Technology
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Aikawa Hiroshi
Department Of Environmental Health Tokai University School Of Medicine
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Shinohara Yukito
Department of Internal Medicine (METABOLISM and ENDOCRINOLOGY), Graduate School of Comprehensive Hum
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Shinohara Yukito
Department Of Cardiology Miyazaki Medical Association Hospital
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Kato Hirotaka
Department Of Mathematical And Design Engineering Faculty Of Engineering Gifu University
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Shinohara Yukito
Department Of Oriental Medicine Tokai University School Of Medicine
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Shinohara Yukito
Tokai Univ. School Of Medicine
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Kato Hirotaka
Department Of Critical Care And Emergency Medicine
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Kato Hirotaka
Department Of Clinical Molecular Medicine Division Of Diabetes Digestive And Kidney Diseases
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