Effect of anticholesterol therapy on soluble ICAM-1 in chronic stroke patients with hyperlipidemia
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概要
- 論文の詳細を見る
Objective: We examined the effects of drug therapy with pravastatin (P) or bezafibrate (B) and diet (D) therapy on serum lipids and soluble intercellular adhesion molecule-1 (sICAM-1) in hyperlipidemic cerebrovascular disease (CVD) patients in the chronic stage. Methods: This study included 36 patients (28 with cerebral infarction and hyperlipidemia and eight with cerebral hemorrhage and hyperlipidemia) divided into three groups: Group P (12 patients), Group B (10 patients), and Group D (14 patients). Before and after treatment, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and sICAM-1 levels were measured. Results: In Group P, Group B and Group D, TC levels were decreased by 30% (p<0.005), 21% (p<0.01), and 21% (p<0.001), LDL-C levels were decreased by 38% (p<0.005), 18% (not significant), and 25% (p<0.005) and TG levels were decreased by 27% (p<0.05), 53% (p<0.005) and 22% (p<0.05), respectively. sICAM-1 levels were decreased by 20% (p<0.005) in Group P, but were not decreased in Group B or Group D. There was no correlation between ΔTC and ΔsICAM-1 (r=0.172). Conclusion: Administration of pravastatin significantly reduced sICAM-1 levels, independently of its decreasing effect on TC and TG in chronic CVD patients. Pravastatin may exert anti-atherosclerotic activity via two distinct mechanisms.
- 東海大学の論文
著者
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KITAGAWA Yasuhisa
Department of Neurology, Tokai University Oiso Hospital
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Shinohara Yukito
Department Of Cardiology Miyazaki Medical Association Hospital
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Shinohara Yukito
Department Of Internal Medicine Tokai University School Of Medicine
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Hata Takashi
Department Of Material Science And Technology Kochi National College Of Technology
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Tomiyasu Hitoshi
Department Of Internal Medicine Kariya Toyota General Hospital
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Tomiyasu Hitoshi
Department Of Internal Medicine Tokai University School Of Medicine:department Of Neurology Yokohama
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Yamamoto Masahiro
Department Of Earth Sciences Okayama University
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ISHIKAWA Kiyoko
Department of Neurology, Yokohama Stroke and Brain Center
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OHTA Tami
Department of Internal Medicine, Tokai University School of Medicine
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Ishikawa Kiyoko
Department Of Neurology Yokohama Stroke And Brain Center
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Kitagawa Yasuhisa
Department Of Internal Medicine Tokai University Oiso Hospital
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Kitagawa Yasuhisa
Department Of Internal Medicine Division Of Neurology Tokai University School Of Medicine
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Hata Takashi
Department Of Computer And Information Sciences Faculty Of Engineering Iwate University
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Hata Takashi
Department Of Internal Medicine Tokai University School Of Medicine:department Of Neurology Yokohama
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Ohta Tami
Department Of Internal Medicine Tokai University School Of Medicine:department Of Neurology Yokohama
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Ishikawa Kiyoko
Department Of Anesthesiology Surugadai Nihon University Hospital
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Yamamoto Masahiro
Department Of Biotechnology The University Of Tokyo
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Yamamoto Masahiro
Department Of Internal Medicine Tokai University School Of Medicine:department Of Neurology Yokohama
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Yamamoto Masahiro
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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