Dielectric Study on Tissue Water by a Time Domain Reflectometry Method

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Dielectric relaxation measurements using a time domain reflectometry method were performed on soleus muscle and brain gray matter of wistar rat in a temperature range of -12℃ to 25℃. Three dielectric relaxation peaks could be found in these tissues. The low frequency peak around 100 Hz could be assigned to electrode polarization, and the intermediate frequency one around 100 kHz could be attributed to migration of counterion in biomaterial. The high frequency peak around 10 GHz could be due to reorientation of bulk water molecules, judging from the relaxation time and relaxation strength. Activation energy of the bulk water for soleus muscle and brain gray matter obtained from temparature dependence of the relaxation time are 17.5 (kJ/mol) and 18.8 (kJ/mol), respectively. These values are in good agreement with that of pure water. The content of bulk water estimated from these relaxation strength at 25℃ are 0.71 (g/cc) and 0.54 (g/cc) respectively. These results suggest that a large amount of tissue water is bulk water, which physical properties are not different from structure and dynamics of pure water.
東海大学の論文