THE INFLUENCE OF SINGLE OR REPEATED PHLEBOTOMY ON THE PHYSIOLOGICAL CONDITION OF NORMAL AND DISEASED RATS
スポンサーリンク
概要
- 論文の詳細を見る
The present experiment was performed to see the influence of phlebotomy on hematology, serum chemistry, and pathology data in rats. When normal rats received a single phlebotomy of 2 or 3 ml blood, erythrocyte count and hematocrit were slightly reduced along with a persistent depression of the blood pressure. In repeated phlebotomy studies, 0.25 to 2 ml each of blood was removed from each rat every other day for 10days. Normal rats from which 0.5 ml and more of blood was withdrawn showed decreases in erythrocyte count and serum iron level concomitant with an increase in reticulocyte count. Similar findings were obtained in rats with CCl_4 liver damage or gentamicin nephrotoxicity, except that those rats hardly exhibited anemia because of a simultaneous occurrence of hemoconcentration. Histopathological findings of the liver and kidney were not different between animals with and without phlebotomy. In phenylhydrazine-treated rats receiving repeated phlebotomy, one rat in the 1-ml phlebotomy and two rats in the 2-ml phlebotomy died from severe anemia. Surviving rats receiving 2-ml phlebotomy showed higher serum GOT and GPT activities together with fatty deposition and/or focal necrosis of hepatocytes. It is concluded that every-other-day phlebotomy of up to 0.25 ml each does not significantly influence the physiological condition of normal or diseased rats.
- 日本トキシコロジー学会の論文
- 1987-02-25
著者
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Suzuki N
Toshiba Corp. Kawasaki Jpn
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FURUHAMA Kazuhisa
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.
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KATO Michiyuki
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.
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Onodera Takeshi
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.
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Kato Masanobu
Mitsubishi Chemical Safety Institute Ltd
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Onodera Takeshi
Drug Safety Research Center Daiichi Pharmaceutical Co.ltd.
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Kato M
Safety Study Department Nihon Bioresearch Inc.
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Kato Michiyuki
Drug Safety Research Cehter Developmental Research Lab. Daiichi Pharmaceutical Co. Ltd.
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Furuhama K
Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn
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Furuhama Kazuhisa
Drug Safety Research Center Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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Furuhama Kazuhisa
Daiichi Pharmaceutical Co. Ltd.
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Onodera T
Drug Safety Research Center Research Institute Daiichi Seiyaku Co. Ltd.
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SUZUKI Norio
Drug Safety Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.
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IGARASHI Kahori
Drug Safety Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.
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Igarashi Kahori
Drug Safety Research Center Research Institute Daiichi Seiyaku Co. Ltd.
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Kato Michiyuki
Drug Safety Research Center Daiichi Pharmaceutical Co. Ltd.
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Kato Masashi
Department Of Bioenvironmental Medline Chiba Univ.:center For Environment Health And Field Sciences
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Suzuki Norio
Drug Safety Research Center Research Institute Daiichi Seiyaku Co. Ltd.
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Suzuki Norio
Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd.
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