<SESSION>TERATOGENIC EFFECT OF TRITIUM WATER AND TRITIUM SIMULATOR ON RAT EMBRYOS
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概要
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The teratogenic effects of tritium water (HTO) on rat embryos were examined and the results obtained were compared with those of tritium simulator (Cs-137 gamma-rays) for determining the relative biological effects (RBE) for the incidence of malformations. Six groups of pregnant rats were injected intraperitoneally with HTO containing 25,50,75,100,125 or 150 mCi HTO/300g B. W. on day 7,8,9,10 or 11 of pregnancy. To obtain accurate RBE values of HTO in rats, five groups of pregnant rats were exposed to Cs-137 gamma-rays by tritium simulator on days 9-18 of pregnancy at exponentially decreasing doses in accordance with body tritium concentration. The rats were sacrificed on day 18 and the offsprings were examined for external and internal malformations. Malformations were seen at the highest incidence of 100% of the survived embryos and 81.3% of total implants in the group given 100 mCi (accumulated doses were about 451 rad) of HTO on day 9 of pregnancy. Tritium simulator accumulated doses of Cs-137 gamma-rays irradiation at 680 rad induced 98.4% malformation in survived embryos and 71.7% of the total implants on day 9 of pregnancy. Both radiations (HTO and Cs-137 gamma-rays) induced similar anomalies of the cardiovascular system in rat embryos. In the present study, comparisons between HTO and tritium simulator showed the teratogenic effect of RBE to be greater than 1.8 and to reach approximately 2.6. The results showed that HTO had stronger teratogenic effects as compared with those of Cs-137 gamma-rays.
- 核融合科学研究所の論文
著者
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SAWADA SHOZO
Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Un
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Satow Yukio
Department Of Envrironment And Mutation Division Of Envrionmental Biology Research Institute For Rad
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Satow Yukio
Department Of Geneticopathology
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Satow Yukio
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Lee Juing
Department Of Geneticopathology
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Sawada Shozo
Department Of Applied Physics Chubu Institute Of Technology
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Sawada Shozo
Department Of Radiation Biology Research Institute For Nuclear Medicine & Biology Hiroshima Univ
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