<SESSION>TRITIUM ABSORPTION THROUGH VARIOUS TYPES OF TRAUMA IN THE SKIN OF HAIRLESS MICE AND ITS PREVENTION

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The rate of absorption of tritium through traumatized skin was assessed by studying its absorption in an animal model. Using female hairless mice (SKH/hr-1), incision, abrasion, thermal burn, and chemical burn caused by HCl were artificially inflicted on the skin of the back of the mice. One drop of tritiated water (HTO) was placed on the traumatized skin and the radioactivity was measured in small blood samples every 10 minute. Although the nature of trauma was quite different from one another, the rate of absorption was 18 times faster for incisions, 12 times faster for abrasions, 10 times faster for therma burns and 1.2 times faster for chemical burns. Similar experiments were performed using tritium vapor because HTO evaporated easily. It was noted that except with incisios, the rate of absorption of tritium vapor was similar to that of HTO in abrasions, thermal burns and chemical burns by HCl. In the case of incisions, the rate of absorption of tritium vapor was significantly slower than that of HTO. Changes in the absorption rate of HTO and tritium vapor during recovery from abrasions were also measured. It was observed that the rate decreased and attained that to normal skin absorption values 10 to 16 days. The inhibition of tritium absorption through abrasion was also studied. Nivea cream showed the most effective inhibition.
核融合科学研究所の論文