Gamma-ray- and Fission Neutron-induced Micronuclei in PHA Stimulated and Unstimulated Human Lymphocytes
スポンサーリンク
概要
- 論文の詳細を見る
Two groups of normal human blood cells, one stimulated with phytohaemaglutinin (PHA) for 24 hr (G_1-S phase of the cell cycle) and one unstimulated (G_0 Phase), were irradiated with ^<60>Co gamma rays or ^<252>Cf radiation. A comparison of radiation-induced micronucleus frequencies showed that the high-dose-rate gamma rays were more effective in inducing micronuclei than low-dose-rate gamma rays. In the cells exposed to low-dose-rate irradiation, there was little difference between the frequency of micronuclei in the G_0 Phase and the G_1-S phase. However, cells in the G_1-S phase were more sensitive than G_0-phase cells to high-dose-rate gamma rays. The relative biological effectiveness of ^<252>Cf neutron irradiation measured in micronucleus assays was consistent with the value obtained for the lethal effect of ^<252>Cf on cultured cells.
- 日本放射線影響学会の論文
著者
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COLOGNE John
Department of Statistics, Radiation Effects Research Foundation
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SAWADA SHOZO
Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Un
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Cologne John
Department Of Statistics Radiation Effects Research Foundation
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Ban Sadayuki
Department Of Genetics Radiation Effects Research Foundation
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Sawada Shozo
Department Of Applied Physics Chubu Institute Of Technology
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DONOVAN MICHAEL
Department of Genetics, Radiation Effects Research Foundation
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Donovan Michael
Department Of Genetics Radiation Effects Research Foundation: (present Address) University Of Roches
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Sawada Shozo
Department Of Radiation Biology Hiroshima University Research Institute For Nuclear Medicine And Bro
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