Radiosensitivity of Peripheral Blood Lymphocytes Obtained from Patients with Cancers of the Breast, Head and Neck or Cervix as Determined with a Micronucleus Assay
スポンサーリンク
概要
- 論文の詳細を見る
The in vitro radiation sensitivities of peripheral blood lymphocytes obtained from 48 normal females and 168 female cancer patients were measured with the cytokinesis-blocking micronucleus assay. Cancer patients group had significantly higher mean baseline micronucleus frequency than normal healthy controls. Breast cancer patients were more radiosensitive than normal individuals. Cervical cancer cases were less radiation sensitive than normal subjects. The relative lack of radiation sensitivity in cervical-cancer cases could be due to modification of the radiosensitivity of patients' immune-responsible cells by human papillomaviruses infection. Normal individuals and cancer patients were classified according to their radiation sensitivity which was evaluated with the radiation-induced micronucleus frequencies. Such a classification will be an important initial step to characterize the radiosensitive, radioresistant, or cancer-prone individuals using specific SNP typing.
- 日本放射線影響学会の論文
著者
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山田 滋
放医研・重粒子医科学センター
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YAMADA Shigeru
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences
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IMAI Takashi
Frontier Res. Ctr., NIRS
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TSUJI Hiroshi
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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Ohno Tatsuya
放射線医学総合研究所重粒子医科学センター病院
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Imai Takashi
Radgenomics Research Group National Institute Of Radiological Sciences
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Imai Takashi
放射線医学総合研究所フロンティア研究センター 放射線感受性遺伝子プロジェクト
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Imai Takashi
University Of Tokyo
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COLOGNE John
Department of Statistics, Radiation Effects Research Foundation
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Imai Takashi
National Inst. Radiological Sci. Chiba Jpn
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BAN Sadayuki
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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NODA Shuhei
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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IWAKAWA Mayumi
Frontier Research Center
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NODA Shuhei
Frontier Research Center
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BAN Sadayuki
Frontier Research Center, National Institute of Radiological Sciences (NIRS)
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KONOMI Chika
Frontier Research Center, National Institute of Radiological Sciences (NIRS)
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OHNO Tatsuya
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences (
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NODA Syuhei
Frontier Research Center, National Institute of Radiological Sciences (NIRS)
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MATUI Yoshifumi
Frontier Research Center, National Institute of Radiological Sciences (NIRS)
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HARADA Yoshinobu
Frontier Research Center, National Institute of Radiological Sciences (NIRS)
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Cologne John
Department Of Statistics Radiation Effects Research Foundation
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Cologne J
Radiation Effects Res. Foundation Hiroshima Jpn
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Ban Sadayuki
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Izumi Takashi
Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.
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ISHIKAWA Takahiro
Natl Inst Radiol Sci
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Hirama Toshiyasu
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Imai Takashi
Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.
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Imai T
Rf Heating Laboratory Naka Fusion Research Establishment Japan Atomic Energy Research Institute
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Noda Syuhei
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Noda Shuhei
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Ohno Tatsuya
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Iwakawa Mayumi
Radgenomics Research Group National Institute Of Radiological Sciences
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Ohta Toshie
Radgenomics Research Group National Institute Of Radiological Sciences
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Harada Yoshinobu
Frontier Research Center National Institute Of Radiological Sciences
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Minfu Y
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Ohno Tatsuya
Department Of Radiation Oncology Graduate School Of Medicine Gunma University
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Iwakawa Mayumi
Res. Center For Charged Particle Therapy National Inst. Of Radiological Sciences
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Matsui Yoshifumi
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Yamada Shigeru
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Yamada Shigeru
Research Center For Advanced Science And Technology The University Of Tokyo
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Konomi Chika
Frontier Research Center National Institute Of Radiological Sciences (nirs)
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Imai Takashi
Frontier Res. Ctr. Nirs
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