Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation
スポンサーリンク
概要
- 論文の詳細を見る
- 2010-10-20
著者
-
Yamamoto Kazuhiro
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
SEKI Takahiro
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
SAKAI Norio
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
斎藤 尚亮
神戸大学・バイオシグナル研究センター
-
斎藤 尚亮
神戸大、バイオシグナル研究センター
-
斉藤 尚亮
神大バイオシグナル
-
斎藤 尚亮
神大バイオシグナル
-
TANAKA Shigeru
Department of Public Health, School of Human Life Sciences, Jumonji University
-
Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Saito Naoaki
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Seki T
Tokyo Inst. Technol. Yokohama
-
Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Saito Naoaki
Lab. Of Mol. Pharmacol. Biosignal Res. Ctr. Kobe University:grad Sch. Of Sci. & Tech. Kobe Unive
-
Seki T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Seki Takahiro
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Serikawa T
Institute Of Laboratory Animals Kyoto University
-
Takahashi Hideyuki
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Japan
-
Ogawa Kota
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
Onji Tomoya
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
Adachi Naoko
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Japan
-
Hide Izumi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
Saito Naoaki
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Japan
-
斎藤 尚亮
神戸大学バイオシグナル研究センター分子薬理分野
-
Yamamoto Kazuhiro
Department Of Biotechnology And Chemistry Kinki University
-
Saito Naoaki
Laboratory Of Molecular Pharmacology Biosignal Research Center Kobe Univ.
-
関 隆広
Inst. Of Lab. Animals Graduate School Of Medicine Kyoto Univ.
-
Seki T
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Sakai Norio
Department Of Developmental Medicine (pediatrics) D-5 Osaka University Graduate School Of Medicine.
-
Ogawa Kota
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Hide Izumi
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Onji Tomoya
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Yamamoto Kazuhiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Seki Takahiro
Department Of Computer Science Tokyo Institute Of Technology:(present Address)ibm Global Service-jap
-
Tanaka Shigeru
Department Of Public Health School Of Human Life Sciences Jumonji University
-
Sakai Norio
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
-
Tanaka Shigeru
Department Of Brain Science And Engineering Graduate School Of Life Science And Systems Engineering
-
Takahashi Hideyuki
Laboratory Of Genetic Engineering Graduate School Of Agriculture Kyoto Prefectural University
-
Takahashi Hideyuki
Laboratory Of Molecular Pharmacology Biosignal Research Center Kobe University
-
Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
-
Tanaka Shigeru
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
-
Adachi Naoko
Laboratory Of Molecular Pharmacology Biosignal Research Center Kobe University
-
Seki Takahiro
Department Of Applied Physics Nagoya University
-
Yamamoto Kazuhiro
Department of Biochemistry, Kinki University
関連論文
- PJ-054 Increased Cardiac Glucocorticoid Contribute to Promoting Cardiac Hypertrophy(Cardiac hypertrophy, basic/clinical(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- プロテインキナーゼCアイソザイムの細胞機能と病態における役割 : 新たな視点からの創薬への応用
- The C-Terminal Region of Serotonin Transporter Is Important for Its Trafficking and Glycosylation
- Examination of growth promotion factors for smooth muscle cells of hypertrophied bladders in rats following partial outlet obstruction
- Analysis of the stable levels of messenger RNA derived from different polymorphic alleles in the vitamin D receptor gene
- Fragmentation of Protein Kinase N (PKN) in the Hydrocephalic Rat Brain
- Antiepileptic Effects of Single and Repeated Oral Administrations of S-312-d, a Novel Calcium Channel Antagonist, on Tonic Convulsions in Spontaneously Epileptic Rats
- Electrophysiological Characterization of Nicotine-Induced Excitaiton of Dopaminergic Neurons in the Rat Substantia Nigra
- Perospirone, a Novel Antipsychotic Agent, Hyperpolarizes Rat Dorsal Raphe Neurons via 5-HT_ Receptor
- Involvement of Ca^ Channels in Abnormal Excitability of Hippocampal CA3 Pyramidal Cells in Noda Epileptic Rats
- IV F10 Abnormal excitability of hippocampal CA3 pyramidal neurons involving abnormal Ca2^+ activity in Noda epileptic rats
- DG-PKCシグナル系の可視化とその異常による疾患
- 脳部位特異的Tet制御γPKC-GFP発現トランスジェニックマウスを用いたγPKCの in vivo ライブイメージング
- ターゲティングを指標にしたプロテインキナーゼC(PKC)の機能解析
- プロテインキナーゼCのターゲティング機構
- PKC活性化によるセロトニントランスポーターの調節機構 : アクチン細胞骨格との関連
- 蛍光蛋白質融合プロテインキナーゼC(PKC)を用いたPKCの機能解析 (研究)
- A1 PKCターゲティング機構の検討 : post-embedding法によるGFP標識PKCのトランスロケーションの解析(一般演題(口演発表),第41回 日本組織細胞化学会総会・学術集会)
- W2-1 PKCシグナル伝達のさらなる理解を求めて : PKCターゲティング機構の解析(細胞内情報伝達への形態学的アプローチ:リン酸化酵素を中心として,ワークショップ2,第41回 日本組織細胞化学会総会・学術集会)
- セロトニントランスポーター
- WS I-2 プロテインキナーゼCのターゲッティング機構と生理機能
- アミノ酸トランスポ-タ- (脳における情報伝達--神経機能素子と素過程) -- (興奮の伝導と伝達 トランスポ-タ-)
- Long-term follow-up of neoadjuvant intraarterial chemotherapy using an original four-lumen double-balloon (4L-DB) catheter for locally advanced uterine cervical cancer
- 4(A-4) CH/π相互作用に着目したプロテインキナーゼCアイソザイム選択的な薬剤の分子設計(口頭発表の部)
- 113(P-62) 発がんプロモーター・インドラクタムVのコンホメーション固定によるプロテインキナーゼCアイソザイム選択的リガンドの分子設計(ポスター発表の部)
- OE-376 Diastolic Wall Strain Reflects the Myocardial Fibrosis in Heart Transplanted Patients(OE64,Heart Failure (Diagnosis) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 3 LV Stiffening as Therapeutic Target on Diastolic Heart Failure(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-322 Analysis of RF signals with chaos theory may provide a novel marker of progressive LV fibrosis.(Echo/Doppler(07)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-316 Blockade of Angiotensin II Type 1 Receptor Improves Hypertensive Diastolic Heart Failure at an Advanced Stage(Cardiac hypertrophy, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-074 Diastolic Color Kinesis Can Noninvasively Detect Pharmacological Effects on LV Diastolic Function(Echo / Doppler-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-072 Usefulness of Diastolic Color Kinetic Imaging in the Assessment of LV Relaxation Regardless of LV Filling Pressure(Echo / Doppler-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Difference of Clinical Characteristics between Hypertensive Patients with and without Diastolic Heart Failure : The Roles of Diastolic Dysfunction and Renal Insufficiency
- PJ-398 Variation in Blood Hemoglobin Levels is Main Contributor to Temporal Changes in Plasma BNP Level in Subjects without Cardiac Diseases(Neurohumoral factors-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Anemia as a Factor That Elevates Plasma Brain Natriuretic Peptide Concentration in Apparently Healthy Subjects
- OJ-231 Strict Blood Pressure Control is Useful for Preventing the Progression of Mild Aortic Stenosis in Hypertensive Patients(OJ39,Valvular Heart Disease/Pericarditis/Cardiac Tumor 2 (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of
- PE-203 Angiotensin Converting Enzyme Inhibitor Slows the Progression of Aortic Stenosis in Hypertensive Patients(Hypertension, clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-199 Diabetes Mellitus is an Accelerator of Aortic Stenosis(Valvular heart disease/Pericarditis/Cardiac tumor(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Role of Activated Renin-Angiotensin System in Myocardial Fibrosis and Left Ventricular Diastolic Dysfunction in Diabetic Patients : Reversal by Chronic Angiotensin II Type 1A Receptor Blockade
- Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction : – Roles of Systolic Function and Ventricular Distensibility –
- Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation
- Light-Cone Effect on Clustering Statistics in Cosmological Redshift Space
- Deciphering Cosmological Information from Redshift Surveys of High-z Objects : The Cosmological Light-Cone Effect and Redshift-Space Distortion
- 26 天然発がんプロモーターの骨格を利用した抗がん剤bryostatin等価体の開発(口頭発表の部)
- PE-284 Angiotensin Converting Enzyme Inhibitor And Angiotensin II Type1 Receptor Antagonist Differently Modulate Extracellular Matrix Regulatory System in Diastolic Heart Failure(Heart Failure, Clinical 10 (M) : PE49)(Poster Session (English))
- PE-182 Angiotensin II type1 Receptor Blocker Suppresses ROS Generation and Inflammatory Changes and Prevents Overt Diastolic Heart Failure in Hypertensive Hearts(Infection/Inflammation/Immunity 2 (H) : PE31)(Poster Session (English))
- Sleep disordered breathing in childhood-onset acid maltase deficiency
- Six novel mutations detected in the GALC gene in 17 Japanese patients with Krabbe disease, and new genotype-phenotype correlation
- Novel mutation of gene coding for glial fibrillary acidic protein in a Japanese patient with Alexander disease
- Systemic T Cell Large Granular Lymphocyte Lymphoma with Multifocal White Matter Degeneration in the Brain of a Japanese Domestic Cat
- Effects of Cardiac Energy Efficiency in Diastolic Heart Failure : Assessment with Positron Emission Tomography with ^C-Acetate
- Involvement of Ca^ Channels in Abnormal Excitability of Hippocampal CA3 Pyramidal Cells in Noda Epileptic Rats
- A New Nonlinear Dynamic Analysis for Myocardial Tissue Characterization : Studies on the Method of Surrogate Echo Data
- Feasibility of Probing Dark Energy with Strong Gravitational Lensing Systems : Fisher-Matrix Approach
- Possible Method to Reconstruct the Cosmic Equation of State from Strong Gravitational Lensing Systems
- Clinical Feasibility of Brain Natriuretic Peptide to Assess the Propensity for Congestive Heart Failure in Patients with Diastolic Dysfunction
- Extracellular Matrix Remodeling as a Determinant of Transition to Diastolic Heart Failure in Hypertensive Hearts : Its Diagnostic and Therapeutic Approach
- Role of Activated Renin-angiotensin System in Myocardial Fibrosis and LV Diastolic Dysfunction in Diabetic Patients : Reversal by Long-term Angiotensin-II Blockade (Diabetes/Obesity 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
- Effects of D-Fraction, a Polysaccharide from Grifola frondosa on Tumor Growt Involve Activation of NK Cells
- Computational Analysis of Molecular Recognition in DNA Base-Sequence and Groove by Methidium Chloride Using Molecular Mechanics Calculation
- Electrophysiological Characterization of Nicotine-Induced Excitaiton of Dopaminergic Neurons in the Rat Substantia Nigra
- Testing General Relativity with the Multipole Spectra of the SDSS Luminous Red Galaxies
- Value of Newly Developed M-mode Tissue Doppler Imaging-based Tracking System for Measurement of Ventricular Mid-wall Dynamics in Hypertrophied Hearts
- Chronic ACE inhibition improves diastolic function and prevents transition to diastolic heart failure even if initiated after compensatory hypertrophic stage
- Value of novel ultrasonic radio-frequency signals analysis in assessing effect of aldosterone inhibition on cardiac structural abnormality
- Diastolic Heart Failure as an Ultimate State of Hypertensive heart : Its Pathophysiology and Prevention
- PJ-053 Anemia as a Factor that Elevates Plasma Brain Natriureteic Peptide Concentration in Healthy Subjects(Heart failure, clinical-17 (M) PJ9,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Effect of Spironolactone on Cardiac Structure as Assessed by Analysis of Ultrasonic Radio-Frequency Signals in Patients With Ventricular Hypertrophy
- Brain Natriuretic Peptide-guided Diagnosis and Therapy of Hypertensive Diastolic Heart Failure : Close Relation between Its Production and Ventricular Fibrosis(Clinical Aspects of Diastolic Failure, The 69th Annual Scientific Meeting of the Japanese Circu
- Long-Term Effect of Aldosterone Inhibition on Cardiac Structural Abnormality as Assessed with Analysis of Ultrasonic Radio-Frequency Signals
- Chronic Angiotensin Converting Enzyme Inhibition Prevented Development of Diastolic Heart Failure in Hypertensive Rats Through Modulation of Hypertrophic Signaling Pathway
- Activated renin angiotensin system deteriorates diastolic function through modulating Ca regulatory proteins and remodeling extracellular matrix
- Augmented collagen degradation rather than inhibition of synthesis accounts for beneficial effects of angiotensin-converting enzyme inhibition in diastolic heart failure
- Differential expression of serum response factor isoforms in the progression of heart failure due to hypertrophy
- Treatment of Fluorocarbon Using Nonthermal Plasma Produced by Atmospheric Discharge
- Spatiotemporal Analysis of the Molecular Interaction between PICK1 and PKC
- Structure and Characteristics of an Endo-β-1,4-glucanase, Isolated from Trametes hirsuta, with High Degradation to Crystalline Cellulose
- Higgs Searches at the Tevatron (広島ヒグス研究会2005-2006)
- D22 Integrated Design Environment for Life Cycle Design(Life cycle engineering and environmentally conscious manufacturing)
- Photocatalytic activity of nanocrystalline TiO_2(B) synthesized from titanium glycolate complex by hydrothermal method(Aqueous Solution Science for Ceramic Processing II)
- Is bone density in the distal femur affected by use of cement and by femoral component design in total knee arthroplasty?
- Mutational analysis of MECP2 in Japanese patients with atypical Rett syndrome
- Mutation analysis of two Japanese patients with Fanconi-Bickel syndrome
- Two-Dimensional Manipulation of Poly(3-dodecylthiophene) using Light-Driven Instant Mass Migration as a Molecular Conveyer
- Dynamic Photoresponsive Functions in Organized Layer Systems Comprised of Azobenzene-containing Polymers
- Role of Hydrogen Bonding in Azobenzene-Urea Assemblies. Structural Evaluations of Multilayers on Solid Substrates
- Bremazocine Recognizes the Difference in Four Amino Acid Residues to Discriminate Between a Nociceptin/Orphanin FQ Receptor and Opioid Receptors
- Focal hepatic steatosis surrounding a metastatic insulinoma
- Pathogenesis of leukodystrophy for Krabbe disease : Molecular mechanism and clinical treatment
- Theoretical Relation between Spatial Resolution and Efficiency of Detection in Scanning Hot Electron Microscope
- Shortening of Detection Time for Observation of Hot Electron Spatial Distribution by Scanning Hot Electron Microscopy
- Reversible Photoswitching Liquid-phase Adsorption on Azobenzene Derivative-grafted Mesoporous Silica
- Transport and Recognition of Aminopeptidase-Resistant Cellobiose-Coupled Tyrosylglycylglycine by Intestinal Na^+/Glucose Cotransporter (SGLT1) : Recognition of Suger Conjugates by SGLT1 Is Much Less Restricted than Transport
- Noise Robust Speech Recognition Using F_0 Contour Information(Speech Dynamics by Ear, Eye, Mouth and Machine)
- Hand-Carried Echocardiography in Assessing Ventricular Function and Valvular Regurgitation
- Structure and Characteristics of an Endo-β-1,4-glucanase, Isolated from Trametes hirsuta, with High Degradation to Crystalline Cellulose
- The Cauchy problem for some class of hyperbolic differential operators with variable multiple characteristics
- Multifocal Primary Lymphoma of Bone:Scintigraphy and MR Findings before and after Treatment
- Long-term β-blocker therapy improves diastolic function even without the therapeutic effect on systolic function in patients with reduced ejection fraction
- Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction : Roles of Systolic Function and Ventricular Distensibility
- Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation