Perospirone, a Novel Antipsychotic Agent, Hyperpolarizes Rat Dorsal Raphe Neurons via 5-HT_<1A> Receptor
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effect of cis-N-[4-[4-(1,2-benz-isozole-3-yl)-1-piperazinyl]butyl] cyclohexane-1,2-dicarboximide hydrochloride (perospirone), a novel antipsychotic agent with high affinities for D2/5-HT2 receptors, on the rat dorsal raphe (DR) neurons, an electrophysiological study was performed using the tight-seal whole-cell patch-clamp technique. Applications of perospirone at the concentration between 10−9 and 10−5 M hyperpolarized the membrane potential and inhibited spontaneous action potentials of the DR neurons in a concentration-dependent manner. This effect of perospirone on DR neurons is similar to that of typical 5HT1A-receptor agonists, including 8-OH-DPAT or tandospirone. In addition, WAY100635, a 5-HT1A-receptor antagonist, inhibited this perospirone-induced hyperpolarization of DR neurons, suggesting that perospirone physiologically acts on DR neurons as a 5HT1A-receptor agonist. These results provide new profiles of perospirone as an antipsychotic drug.
- 社団法人 日本薬理学会の論文
- 2003-09-01
著者
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AMANO Taku
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SEKI Takahiro
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SAKAI Norio
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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斎藤 尚亮
神戸大学・バイオシグナル研究センター
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斎藤 尚亮
神戸大、バイオシグナル研究センター
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Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Matsubayashi Hiroaki
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SHIWA Tsuguka
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Sasa M
Department Of Pharmacology Hiroshima University School Of Medicine
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Amano T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Pharamacology Hiroshima University School Of Medicine
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Sasa Masashi
Institute Of Laboratory Animals Graduate School Of Medicine Kyoto University
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Shiwa Tsuguka
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Seki T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Seki Takahiro
Chemical Resources Laboratory Tokyo Institute Of Technology
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Seki Takahiro
Photofunctional Chemistry Division Research Laboratory Of Resources Utilization Tokyo Institute Of T
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Seki Takahiro
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Mukai Hideyuki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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Amano Taku
Department Of Pharmacology Hiroshima University School Of Medicine
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斎藤 尚亮
神戸大学バイオシグナル研究センタｰ分子薬理分野
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Matsubayashi Hiroaki
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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関 隆広
Inst. Of Lab. Animals Graduate School Of Medicine Kyoto Univ.
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Matsubayashi Hiroaki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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Sakai Norio
Department Of Developmental Medicine (pediatrics) D-5 Osaka University Graduate School Of Medicine.
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Seki Takahiro
Department Of Computer Science Tokyo Institute Of Technology:(present Address)ibm Global Service-jap
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Sakai Norio
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Shiwa Tsuguka
Department Of Endocrinology Hiroshima University Faculty Of Medicine
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Seki Takahiro
Department Of Applied Physics Nagoya University
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