Is Compensatory Vasoconstrictor Tone in the Hindquarter Vascular Region Induced by Hemorrhage in Conscious Spontaneously Hypertensive Rats?

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概要

• 論文の詳細を見る

• We investigated whether a compensatory vasoconstrictor action would be induced by a hypotensive intervention in the hindquarter vascular region of conscious spontaneously hypertensive rats (SHRs). Mean arterial pressure and hindquarter blood flow were recorded. After hemorrhage (withdrawing blood, 0.3 ml/100 g body weight), hindquarter resistance (HQR) was increased significantly. The decrease in HQR induced by the administration of a ganglionic blocker (C6; 25 mg/kg, i.v.) was significantly greater in SHRs with hemorrhage than in those without hemorrhage. The present results suggest that a detectable hindquarter compensator tone occurs due to hemorrhage in SHRs, although an abnormal substantial vasoconstrictor tone already exists in the hindquarters.

• 社団法人 日本薬理学会の論文
• 2001-01-01

著者

• AMANO Taku

  Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi

• IIDA Noriko

  Department of Clinical Laboratory, Tsukuba University Hospital

• Amano Taku

  Department Of Pharamacology Hiroshima University School Of Medicine

• Amano Taku

  Department Of Pharmacology Hiroshima University Faculty Of Medicine

• Iida Noriko

  Department Of Clinical Laboratory Tsukuba University Hospital

• Iida Noriko

  First Department Of Internal Medicine Faculty Of Medicine Hiroshima University

• Sugino Hiroshi

  First Department of Internal Medicine, Hiroshima University

• Amano Taku

  Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro

• TERANISHI Yasuhiro

  Department of Physiology, School of Medicine, Hiroshima University

• Sugino H

  First Department Of Internal Medicine University Of Obihiro School Of Veterinary Medicine

• Sugino Hiroshi

  First Department Of Internal Medicine Faculty Of Medicine Hiroshima University

• ISHIOKA Norio

  First Department of Internal Medicine, University of Obihiro School of Veterinary Medicine

• Teranishi Y

  広島大学 生理

• Teranishi Yasuhiro

  Second Department Of Physiology Hiroshima University

• Teranishi Yasuhiro

  Department Of Physiology School Of Medicine Hiroshima University

• Teranishi Yasuhiro

  Department Of Physiology Hiroshima University Faculty Of Medicine

• Iida Noriko

  Department Of Clinical Biochemistry Tokyo University Of Pharmacy And Life Science

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