Inhibitory Effects of 7-OH-DPAT, Dopamine D3-Receptor Agonist, on Nucleus Accumbens Neurons.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of 7-hydroxy-2-(<I>N</I>, <I>N</I>-di-<I>n</I>-propylamino)tetralin (7-OH-DPAT), a dopamine D<SUB>3</SUB>-receptor agonist, on neuronal activities of the nucleus accumbens (Acc) were examined in chloral hydrate-anesthetized rats. Spikes elicited by stimulation of the parafascicular nucleus were dose-dependently inhibited by microiontophoretic application of dopamine and 7-OH-DPAT. Glutamate-induced firing was also inhibited by these drugs. These findings suggest that D<SUB>3</SUB> receptors are also involved in the postsynaptic inhibition of Acc neuron by dopamine.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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MOMIYAMA Toshihiko
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Matsubayashi Hiroaki
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Momiyama Toshihiko
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Amano Taku
Department of Pharmacology, Hiroshima University School of Medicine
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Matsubayashi Hiroaki
Department of Pharmacology, Hiroshima University School of Medicine
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