The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels
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概要
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Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na+ current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the treatment of LTG, Nav1.4 Na+ current was inhibited in a dose-dependent manner. Moreover, 100 μM LTG decreased Nav1.4 Na+ current around 40% and shifted the V1/2 of the inactivation curve to the hyperpolarization side by 20.96 mV. These findings suggest that LTG inhibits Nav1.4 Na+ current and modifies the kinetics of the inactivated state.
- 公益社団法人 日本薬理学会の論文
著者
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Amano Taku
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Nakatani Yoshihiko
Department Of Physics Faculty Of Engineering Science Osaka Univesity:(present Address) Matsushita El
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Amano Taku
Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare, Japan
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Masuko Haruka
Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare, Japan
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Nakatani Yoshihiko
Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare, Japan
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Nakatani Yoshihiko
Department of Pharmacology, School of Pharmacy, International University of Health and Welfare
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