Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of a nitric oxide (NO)-producing agent, sodium nitroprusside, on <I>N</I>-methyl-D-aspartate (NMDA)receptor activation in the cultured retinal neurons of rats were examined. NMDA in a Mg<SUP>2+</SUP> free medium evoked inward currents at the resting membrane potential. Inward currents were also evoked by kainate. Sodium nitroprusside markedly reduced the NMDA-induced currents without affecting those induced by kainate. These results suggest the possible existence of a negative feed back system of NO which serves to regulate the activation of NMDA receptors in retinal neurons.
- 公益社団法人 日本薬理学会の論文
著者
-
SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
Honda Yoshihito
Department Of Ophthalmology And Visual Science Graduate School Of Medicine Kyoto University
-
Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
-
UJIHARA Hisamitsu
Department of Neuropsychiatry, Kochi Medical School
-
Kashii Satoshi
Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University
-
Tamura Yutaka
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
Kashii Satoshi
Department of Ophthalmology, Faculty of Medicine, Kyoto University
-
Yokota Takeharu
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
Honda Yoshihito
Department of Ophthalmology, Faculty of Medicine, Kyoto University
-
Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
Sasa Masashi
Department of Pharmacology, School of Medicine, Hiroshima University
関連論文
- Perospirone, a Novel Antipsychotic Agent, Hyperpolarizes Rat Dorsal Raphe Neurons via 5-HT_ Receptor
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl^- Influx
- Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Serofendic Acid Promotes Stellation Induced by cAMP and cGMP Analogs in Cultured Cortical Astrocytes
- Transient Intraocular Pressure Elevation after Trabeculotomy and its Occurrence with Phacoemulsification and Intraocular Lens Implantation
- Multicenter Genetic Study of Retinitis Pigmentosa in Japan : I. Genetic Heterogeneity in Typical Retinitis Pigmentosa
- Multicenter Genetic Study of Retinitis Pigmentosa in Japan : II. Prevalence of Autosomal Recessive Retinitis Pigmentosa
- MER Rat Strain: A New Type of Genetic Model in Epilepsy Research
- PJ-104 Serofendic Acid, a Novel Substance Extracted from Fetal Calf Serum, Protects against Oxidative Stress in Neonatal Rat Cardiac Myocytes(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annua
- Pars Plana Vitrectomy for Epiretinal Membrane Associated with Sarcoidosis
- Reproducibility of Scanning Laser Doppler Flowmetry in the Rat Retina and Optic Nervehead
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Primary neurotransmitters and regulatory substances onto vestibular nucleus neurons
- Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- The Parkinsonian Models : Invertebrates to Mammals
- Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
- Foreword(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Co-culture With the Striatum Attenuates N-Methyl-D-aspartate Cytotoxicity in Dopaminergic Neurons of Rat Mesencephalic Slice Cultures
- Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity
- Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons
- Suppressive effect of zinc ion on iNOS expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocytes
- Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
- EFFECTS OF OPIOID PEPTIDES ON NEURONAL ACTIVITIES OF THE CNS : STUDIES USING MICROELECTROPHORETIC METHOD
- Human V5 demonstrated by magnetoencephalography using random dot kinematograms of different coherence levels
- Neuroprotective action of donepezil mediated by neuronal nicotinic receptors
- A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
- Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
- Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
- Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
- Endogenous Factors Regulating Neuronal Death Induced by Radical Stress(Mitochondria and Neuroprotection)
- Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
- Ether Extract of Fetal Cakf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity
- ELECTROPHYSIOLOGICAL STUDY ON DOPAMINERGIC SYSTEM IN THE CAUDATE NUCLEUS
- Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
- Long-lasting Antiepileptic Effects of Levetiracetam against Epileptic Seizures in the Spontaneously Epileptic Rat (SER) : Differentiation of Levetiracetam from Conventional Antiepileptic Drugs
- Separation of Antiepileptogenic and Antiseizure Effects of Levetiracetam in the Spontaneously Epileptic Rat (SER)
- Activation by N-Acetyl-L-Aspartate of Acutely Dissociated Hippocampal Neurons in Rats via Metabotropic Glutamate Receptors
- IV F2 Is levetiracetam distinct from conventional antiepileptic drugs by antiepileptogenic properties in spontaneous epileptic rats?
- Excitation of Rat Striatal Large Neurons by Dopamine and/or Glutamate Released From Nerve Terminals via Presynaptic Nicotinic Receptor (α_4β_2 Type) Stimulation
- Enhanced Calcium Influx in Hippocampal CA3 Neurons of Spontaneously Epileptic Rats
- Inhibition by γ-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats
- Effects of Perospirone, a Novel Antipsychotic Agent, on the Dopaminergic Neurons in the Rat Ventral Tegmental Area
- Antiepileptic Effects of 20-Hydroxyecdysone on Convulsive Seizures in Spontaneously Epileptic Rats
- D_2 Receptor Activation in Distinct Striatal Neurons in Comparison with D_3 Receptors
- Electrophysiological and Pharmacological Characteristics of lonotropic Glutamate Receptors in Medial Vestibular Nucleus Neurons: A Whole Cell Patch Clamp Study in Acutely Dissociated Neurons
- Role of Vitronectin Receptor-Type Integrins and Osteopontin in Ischemia-Induced Retinal Neovascularization
- Existence of Ionotropic Glutamate Receptor Subtypes in Cultured Rat Retinal Ganglion Cells Obtained by the Magnetic Cell Sorter Method and Inhibitory Effects of 20-Hydroxyecdysone, a Neurosteroid, on the Glutamate Response
- Protection Against Glutamate Neurotoxicity in Retinal Cultures by Acidic Conditions
- Potentiation of GABA - Induced Inhibition by 20 - Hydroxyecdysone, a Neurosteroid, in Cultured Rat Cortical Neurons
- Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature
- Cold Exposure Enhances Nitroxidergic Nerve-Mediated Vasodilatation in Canine Nasal Mucosa
- DISTRIBUTION OF FODRIN AND α-ACTININ IN THE RAT RETINAL PIGMENT EPITHELIUM IN VIVO
- CYTOCHEMICAL DEMONSTRATION OF LECTIN BINDING SITES IN ROD PHOTORECEPTOR CELLS AND INTERPHOTORECEPTOR MATRIX OF RAT RETINAS BY LABELING FROZEN THIN-SECTIONS WITH VARIOUS LECTINS
- Selective Blockade of P-type Calcium Channels by Lead in Cultrued Hippocampal Neurons
- Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
- Long-Term Outcome After Radiation Therapy for Subfoveal Choroidal Neovascularization Associated with Age-Related Macular Degeneration
- Effects of Talipexole on Contraversive Rotation and Functional Impairment in MPTP-Induced Chronic Hemiparkinsonian Monkeys
- Mechanism Underlying the Therapeutic Effects of Electroconvulsive Therapy (ECT) on Depression
- Generation of knock-in mice carrying third cones with spectral sensitivity different from S and L cones
- Long-Term Antiepileptic Effects of Chronic Intake of CNK-602A, a Thyrotropin-Releasing Hormone Analogue, on Spontaneously Epileptic Rats
- Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
- Effects of L-DOPA on neuronal activities in CA1 of hippocampal slices
- Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
- Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
- Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
- SURGICAL RESULTS AND COMPLICATIONS OF TRABECULECTOMY WITH INTRAOPERATIVE APPLICATION OF MITOMYCIN C
- Analysis of Cyclosporin A-Induced Reversible Cortical Blindness by Diffusion-Weighted Magnetic Resonance Imaging Techniques
- Electrical Activity of the Human Retina in Vitro(SYMPOSIUM ON ELECTRORETINOGRAPHY)
- ANTAGONIZING EFFECTS OF β-ADRENERGIC BLOCKERS ON LOCUS COERULEUS-INDUCED INHIBITION OF TRIGEMINAL NUCLEUS NEURONS
- IMPAIRMENT BY 6-HYDROXYDOPAMINE OF LOCUS COERULEUS-INDUCED MONOSYNAPTIC POTENTIAL IN THE SPINAL TRIGEMINAL NUCLEUS
- EFFECTS OF 7-ETHOXYCARBONYL-6, 8-DIMETHYL-4-HYDROXYMETHYL-1(2H)-PHTHALAZINONE (EG626) ON THE SPINAL TRIGEMINAL NUCLEUS, VENTRAL POSTEROMEDIAL NUCLEUS, AND SENSORY CORTEX
- Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- SELECTIVE EFFECT OF ETHANOL ON THE VESTIBULAR NUCLEUS NEURONS IN THE CAT
- Prognostic Factors for Hypotensive Effects of Isopropyl Unoprostone in Eyes With Primary Open-Angle Glaucoma
- IMMUNOCYTOCHEMICAL STUDY OF FODRIN IN THE RAT RETINAL PIGMENT EPITHELIUM
- DOPAMINERGIC INHIBITION FROM SUBSTANTIA NIGRA OF CAUDATE NEURONS ACTIVATED BY CORTICAL STIMULATION
- EFFECTS OF HARMALINE ON MEMBRANE EXCITABILITY AND ATPase ACTIVITY OF THE CRAYFISH GIANT AXON
- LOCAL ANESTHETIC ACTIVITY OF β-ADRENERGIC BLOCKING DRUGS IN THE CRAYFISH GIANT AXON, WITH REFERENCE TO CALCIUM ION
- Failure of Repeated Electroconvulsive Shock Treatment on 5-HT_4-Receptor-Mediated Depolarization Due To Protein Kinase A System in Young Rat Hippocampal CA1 Neurons
- BRADYKININ-INDUCED FLEXOR REFLEX OF RABBIT HINDLIMB FOR COMPARING ANALGESICS
- Developmental expression of β-catenin in mouse retina
- COMPARISON BETWEEN FLUORIMETRIC AND RADIOCHEMICAL ASSAYS OF IONTOPHORETICALLY RELEASED NORADRENALINE FROM A SEVEN-BARRELED MICROPIPETTE
- Release of Sympathetic Neurotransmitter Evoked by Electrical Stimulation Is Increased in the Chronically Decentralized Artery.
- Effects of diphenhydramine iontophoretically applied onto neurons in the medial and lateral vestibular nuclei.
- Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation.
- Effects of ethanol applied by electrosmosis on neurons in the lateral and medial vestibular nuclei.
- Ethanol inhibits vestibular and caloric nystagmus without affecting optokinetic nystagmus in rabbits.
- Inhibition by intravenously administered sodium bicarbonate of neuronal activity in medial vestibular nucleus neurons.
- Inhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus.
- Failure of Repeated Electroconvulsive Shock Treatment on 5-HT4-Receptor-Mediated Depolarization Due To Protein Kinase A System in Young Rat Hippocampal CA1 Neurons
- A noradrenaline-induced inhibition from locus coeruleus of nucleus accumbens neuron receiving input from hippocampus.
- THE ROLE OF THIAMINE ON EXCITABLE MEMBRANE OF CRAYFISH GIANT AXON
- Inhibitory Effects of 7-OH-DPAT, Dopamine D3-Receptor Agonist, on Nucleus Accumbens Neurons.
- Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation.
- Effects of Protein Kinase C on the Muscarinic Excitation of Rat Adrenal Chromaffin Cells.
- Evidence for the Excitatory Cholinergic Innervation in the Rabbit Portal Vein.
- Muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra.