Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
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概要
- 論文の詳細を見る
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer’s disease. To elucidate whether donepezil causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil (10 μM) significantly potentiated the neurite outgrowth evoked by low (1 ng/ml) and high (50 ng/ml) concentrations of NGF. The effect of donepezil (1 – 10 μM) was concentration-dependent. The enhancement of neurite outgrowth caused by donepezil was not blocked by the acetylcholine receptor (AChR) antagonists mecamylamine and scopolamine. Furthermore, the AChR agonists nicotine and carbachol did not affect the neurite outgrowth induced by NGF. Donepezil (10 μM) also significantly potentiated neurite outgrowth evoked by dibutyryl cyclic AMP. Moreover, donepezil potentiated the NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK). These results suggest that donepezil potentiated neuronal differentiation by enhancing the activation of ERK.
- 社団法人 日本薬理学会の論文
- 2007-08-20
著者
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Katsuki Hiroshi
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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Kume Toshiaki
京都大学 薬学研究科生体機能解析学
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学分野
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学
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Kume Toshiaki
同志社女子大学 医療薬学科薬理学
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Kume Toshiaki
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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Akaike A
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
京都大学 薬学研究科生体機能解析学
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Akaike Akinori
京都薬科大学 病態生理
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Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Kume Toshiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Niidome Tetsuhiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences,
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Sugimoto Hachiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences,
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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ODA Toru
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Sugimoto Hachiro
Dep. Of Neuroscience For Drug Discovery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Sugimoto Hachiro
Department Of Neuroscience For Drug Discovery Graduate School Of Pharmaceutical Sciences Kyoto Unive
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Niidome Tetsuhiro
Dep. Of Neuroscience For Drug Discovery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Niidome Tetsuhiro
Department Of Neuroscience For Drug Discovery Graduate School Of Pharmaceutical Sciences Kyoto Unive
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Katsuki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Akaike Akinori
Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Katsuki Hiroshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Kume T
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Oda Toru
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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