EFFECTS OF INDOMETHACIN AND THE OTHER ANTI-INFLAMMATORY AGENTS ON ACTIVATION OF DORSAL HORN CELL IN THE SPINAL CORD INDUCED BY INTRA-ARTERIAL INJECTION OF BRADYKININ
スポンサーリンク
概要
- 論文の詳細を見る
Bradykinin (1-2 μg) injected into the femoral artery of the rabbit induced a marked increase in the firing rates of the dorsal horn cells (lamina V cells). This response was markedly inhibited by intravenous administration of indomethacin (1.0 mg/kg), acetylsalicylic acid (20 mg/kg), aminopyrine (50 mg/kg) and oxyphenbutazone (20 mg/kg) in both intact and spinal preparations. Moreover, the intra-arterial injection of these agents depressed the response in lower doses. With these same low doses, no significant suppression occurred when the intravenous route was used. These results indicate that indomethacin and other anti-inflammatory agents tested suppress the bradykinin-induced response of the dorsal horn cell at the periphery, probably at the paravascular sensory nerve.
著者
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Doi Takayuki
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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Kawasaki Kazuo
Department Of Ophthalmology Kanazawa University School Of Medicine
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Satoh Masamichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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Takagi Hiroshi
Department Of Bioscience Fukui Prefectural University
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Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
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KAWASAKI Kazuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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DOI Takayuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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AKAIKE Akinori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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