Involvement of Glutamate Receptors Within the Central Nucleus of the Amygdala in Naloxone-Precipitated Morphine Withdrawal- Induced Conditioned Place Aversion in Rats

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概要

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• Chronic use of morphine leads to physical and psychological dependence. The amygdala is known to be involved in the expression of emotion such as anxiety and fear, and several studies have shown that the central nucleus of the amygdala (CeA) is involved in morphine dependence. In the present study, we investigated the role of glutamate receptors within the CeA in the negative affective component of morphine abstinence by evaluating naloxone-precipitated withdrawal-induced conditioned place aversion (CPA) in morphine-dependent rats. We found that microinjection of the AMPA/kainate-glutamate-receptor antagonist CNQX (30 nmol/side) into the bilateral CeA significantly attenuated the naloxone-precipitated withdrawal-induced CPA, as well as several somatic signs, in morphine-dependent rats, without preference or aversive effects by itself in non-dependent rats. Furthermore, microinjection of the non-competitive NMDA-receptor antagonist MK-801 (30 nmol/side) or competitive NMDA-receptor antagonist <sc>D</sc>-CPPene (0.01 and 0.1 nmol/side) into the CeA significantly attenuated the naloxone-precipitated morphine withdrawal-induced CPA, but not somatic withdrawal signs. These results suggest that the activation of AMPA/kainate and NMDA receptors within the CeA play a crucial role in the negative affective component of morphine abstinence.

• 社団法人 日本薬理学会の論文
• 2002-04-01

著者

• WATANABE Takeshi

  Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University

• Yamamoto Rie

  Department Of Cardiovascular Science And Medicine

• NAKAGAWA Takayuki

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamamoto Rie

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• SATOH Masamichi

  Department of molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto university

• Yamamoto Rie

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakagawa Takayuki

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakagawa Takayuki

  Department Of Fisheries Faculty Of Agriculture Kinki University

• Maeda Akifumi

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• MINAMI Masabumi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Minami Masabumi

  Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University

• Nakagawa Takayuki

  Dep. Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn

• Satoh Masamichi

  Department Of Molecular Pharmacology Faculty Of Pharmaceutical Science Kyoto University

• Satoh Masamichi

  Yasuda Women's Univ. Jpn

• Watanabe T

  Tokyo Univ. Fisheries Tokyo Jpn

• Watanabe Takeshi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Sato Masamichi

  Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School

• Satoh Masamichi

  Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School

• Watanabe Takeshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

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