Involvement of β_2-Adrenergic and μ-Opioid Receptors in Antinociception Produced by Intracerebroventricular Administration of α,β-Methylene-ATP
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概要
- 論文の詳細を見る
The present study examined what kind of receptors are involved in the antinociception produced by intracerebroventricular (i.c.v.) administration of α,β-methylene-ATP using antagonists at adrenergic, serotonin or opioid receptors. Antinociceptive effect of α,β-methylene-ATP (10 nmol/rat) was significantly attenuated by subcutaneous pretreatment with propranolol and naloxone, but not phentolamine or methysergide, at a dose of 10 mg/kg. I.c.v. pretreatment with propranolol (100 nmol/rat), butoxamine (100 nmol/rat), ICI-118,551 (100 nmol/rat) and naloxone (30 nmol/rat) significantly attenuated the antinociceptive effect of α,β-methylene-ATP. However, i.c.v. pretreatment with atenolol (100 nmol/rat), naltrindole (30 nmol/rat) or nor-binaltorphimine (30 nmol/rat) did not show any significant effects. These results suggest that supraspinal β2-adrenergic and μ-opioid receptors are involved in the antinociceptive effect of i.c.v. administered α,β-methylene-ATP.
- 社団法人 日本薬理学会の論文
- 2001-08-01
著者
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NAKAGAWA Takayuki
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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SATOH Masamichi
Department of molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto university
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Nakagawa Takayuki
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Nakagawa Takayuki
Department Of Fisheries Faculty Of Agriculture Kinki University
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MINAMI Masabumi
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Minami Masabumi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Nakagawa Takayuki
Dep. Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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FUKUI Masato
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Fukui Masato
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Satoh Masamichi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Science Kyoto University
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Satoh Masamichi
Yasuda Women's Univ. Jpn
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Sato Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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