Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
スポンサーリンク
概要
- 論文の詳細を見る
3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures. Here we investigated the mechanism of augmented serotonin release from the slice cultures. Sustained MDMA exposure had no effect on MDMA-induced serotonin efflux in the synaptosomal fraction, whereas either tetrodotoxin, calcium channel inhibitors, or AMPA-receptor antagonists significantly attenuated the augmented serotonin release. These results suggest that the increase in Ca2+-dependent exocytotic serotonin release is mediated through activation of AMPA receptors and responsible for the sustained MDMA-induced augmentation of serotonin release.
著者
-
KANEKO Shuji
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
NAKAGAWA Takayuki
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
Nagayasu Kazuki
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University,
-
Kitaichi Maiko
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University,
-
Shirakawa Hisashi
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University,
-
Nakagawa Takayuki
Department Of Fisheries Faculty Of Agriculture Kinki University
-
Kaneko Shuji
Department Of Applied Biological Chemistry Graduate School Of Agricultural Science Kobe University
-
Kitaichi Maiko
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Shirakawa Hisashi
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Nagayasu Kazuki
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Shirakawa Hisashi
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
-
Kitaichi Maiko
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
-
Nagayasu Kazuki
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
関連論文
- Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes
- Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
- Neuropsychotoxicity of Abused Drugs : Molecular and Neural Mechanisms of Neuropsychotoxicity Induced by Methamphetamine, 3,4-Methylenedioxymethamphetamine (Ecstasy), and 5-Methoxy-N,N-diisopropyltryptamine (Foxy)
- Neuropsychotoxicity of Abused Drugs : Clinical and Basic Research and Drug Development : Preface
- Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion
- A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
- Collocational Analysis of Life Science English (1) : Lists of common collocates of possibility, probability, implication, involvement, absence, presence, evidence
- Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
- Ether Extract of Fetal Cakf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity
- Presence of Cysteine Endopeptidase in the Pyloric Caeca of Pacific Mackerel Scomber japonicus and Its Purification and Characterization
- MCH-09 MICROFABRICATED ACOUSTIC SENSOR WITH FREQUENCY SELECTIVITY AND ELECTRIC SIGNAL CONVERSION FOR NOVEL ARTIFICIAL COCHLEAR SYSTEM(Micro/Nanomechatronics III,Technical Program of Oral Presentations)
- Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma
- (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis
- Involvement of Glutamate Receptors Within the Central Nucleus of the Amygdala in Naloxone-Precipitated Morphine Withdrawal- Induced Conditioned Place Aversion in Rats
- The Involvement of Aldose Reductase in Alterations to Neurotrophin Receptors and Neuronal Cytoskeletal Protein mRNA Levels in the Dorsal Root Ganglion of Streptozotocin-Induced Diabetic Rats
- Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat
- Facilitative Effect of a Glutamate Transporter Inhibitor (2S,3S)-3-{3-[4-(Trifluoromethyl)benzoylamino]benzyloxy} aspartate on the Expression of Methamphetamine-Induced Behavioral Sensitization in Rats
- Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain : possible involvement in the development of neuropathic pain
- Involvement of Locus Coeruleus Noradrenergic Neurons in Supraspinal Antinociception by α, β-Methylene-ATP in Rats
- Involvement of β_2-Adrenergic and μ-Opioid Receptors in Antinociception Produced by Intracerebroventricular Administration of α,β-Methylene-ATP
- Sensitization of the Adenylyl Cyclase System in Cloned κ-Opioid Receptor-Transfected Cells Following Sustained Agonist Treatment : A Chimeric Study Using G Protein α_/α_q Subunits
- Bremazocine Recognizes the Difference in Four Amino Acid Residues to Discriminate Between a Nociceptin/Orphanin FQ Receptor and Opioid Receptors
- Pyridinoline concentrations in muscular and skin collagen of fish and relationship between collagen solubility and pyridinoline concentration in fish muscular collagen
- Influence on Post-mortem Rigor of Fish Body and Muscular ATP Consumption by the Destruction of Spinal Cord in Several Fishes
- Glyceraldehyde 3-Phosphate Dehydrogenase, a Specific Sarcoplasmic Protein Insolubilized during Cold-storage of Sardine
- Post-mortem Change of Three-dimensional Structure of Collagen Fibrillar Network in Fish Muscle Pericellular Connective Tissues Corresponding to Post-mortem Tenderization
- Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
- Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
- Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
- Purification and Characterization of an Extracellular Laccase from Phlebia radiata Strain BP-11-2 That Decolorizes Fungal Melanin
- Purification and Characterization of an Extracellular Laccase from Phlebia radiata Strain BP-11-2 That Decolorizes Fungal Melanin
- Roles of β- and α2-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain–Induced Aversion in Rats
- Comparative Study of Anti-Oncogenic MicroRNA-145 in Canine and Human Malignant Melanoma
- Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
- Differential Contribution of Spinal Mitogen-Activated Protein Kinases to the Phase of Long-Lasting Allodynia Evoked by Intrathecal Administration of ATP in Rats(Pharmacology)
- Spinal Astrocytes as Therapeutic Targets for Pathological Pain
- Roles of β- and α_2-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain-Induced Aversion in Rats
- Spinal Astrocytes as Therapeutic Targets for Pathological Pain
- 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering
- Electrically Evoked Auditory Brainstem Response by Using Bionic Auditory Membrane in Guinea Pigs
- A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide
- A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide