SUPPRESSIVE EFFECT OF CIRAMADOL ON THE BRADYKINININDUCED ACTIVITIES OF THE LAMINA V-TYPE CELLS OF THE RAT SPINAL DORSAL HORN
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概要
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The effects of a new analgesic drug, ciramadol, on single neuronal activities of lamina V-type celles of the spinal dorsal horn were investigated in spinal rats when applied microelectrophoretically to the cells or administered systemically. In the majority of lamina V-type cells examined, ciramadol inhibited the activities induced by intra-arterial injection of bradykinin (painful stimulation) but not those induced by mechanical noxious and innocuous stimuli. These results directly evidence that ciramadol acts on the lamina V-type cells of the spinal dorsal horn to block the bradykinin-induced (nociceptive) activities there.
- 公益社団法人日本薬学会の論文
著者
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Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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Takagi Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
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KUBOTA ATSUHIKO
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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Kubota Atsuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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