POSSIBLE MECHANISM INVOLVED IN THE INHIBITORY ACTION OF U-50,488H, AN OPIOID κ AGONIST, ON GUINEA PIG HIPPOCAMPAL CA3 PYRAMIDAL NEURONS IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
Intracellular recordings of the CA3 pyramidal neurons in the guinea pig hippocampus were made in vitro. U-50 488H (100 μM), a selective opioid κ agonist, decreased the synaptic response produced by stimulation of the mossy fibers but did not affect the membrane potential, the input resistance and the generation of the Na^+ spikes or the Ca^<2+> spikes. Iontophoretically applied U-50 488H depressed the depolarization produced by L-glutamate. U-50 488H (100 μM) also depressed the consistent depolarization produced by veratrine (3×10^<-5> g/ml) and this effect was partially antagonized by naloxone. Moreover, application of U-50 488H led to a disappearance of the anomalous rectification. These results suggest that U-50 488H depresses the synaptic activities of the CA3 pyramidal neurons by inhibiting a subtype of the Na^+ channel, "Na^+ channel type II"which slowly closes, of the soma and/or the dendrites of the neurons.
- 公益社団法人日本薬学会の論文
著者
-
TAKAGI Hiroshi
Department of Surgery II, University School of Medicine
-
SATOH Masamichi
Department of molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto university
-
ISHIHARA Kumatoshi
Department of Pharmacotherapy, Hiroshima University School of Medicine
-
Takagi Hiroshi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
-
Takagi H
Toyama Chemical Co. Ltd. Toyama Jpn
-
IWAMA TOSHI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
-
Ishihara Kumatoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Satoh M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Satoh Masamichi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Science Kyoto University
-
Iwama Toshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
-
Takagi Hiroshi
Department Of Bioscience Fukui Prefectural University
-
Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
-
Ishihara Kumatoshi
Department of Neurology and Neurosurgery, The Montreal Neurological Institute and Hospital
関連論文
- Detection of ras Gene Mutations in Perioperative Peripheral Blood with Pancreatic Adenocarcinoma
- Immunohistochemical and Molecular Biological Studies of Serous Cystadenoma of the Pancreas
- Detection of Mutant K-ras in Dissected Paraaortic Lymph Nodes of Patients with Pancreatic Adenocarcinoma
- Neutrophil Behavior in Pancreas and Liver and the Role of Nitric Oxide in Rat Acute Pancreatitis
- Peritoneal Washing Cytology Combined with Immunocytochemical Staining and Detecting Mutant K-ras in Pancreatic Cancer : Comparison of the Sensitivity and Availability of Various Methods
- Detection of Hepatic Micrometastasis in Pancreatic Adenocarcinoma Patients by Two-stage Polymerase Chain Reaction/Restriction Fragment Length Polymorphism Analysis
- Temperature Dependence of the Yb 4f Spectra in Yb_4Bi_3 Probed by Photoemission Spectroscopy
- Bow Hunter's Stroke Associated with an Aberrant Course of the Vertebral Artery : Case Report
- Clinical Significance of Carcinoma Invasion of the Extrapancreatic Nerve Plexus in Pancreatic Cancer
- Cloning, Sequence Analysis, and Expression in Escherichia coli of the Gene Encoding Monovalent Cation-activated Levodione Reductase from Corynebacterium aquaticum M-13
- Experimental analysis of the fiber connection of the peptidergic systems in the central nervous system of the rat. I.
- Distribution of somatostatin in the rat central nervous system. I. Ontogenical aspects.
- Regional distribution of somatostatin in the avian central nervous system.
- Distribution of somatostatin in the fish brain (Carp)
- Distribution of somatostatin in the frog brain, Rana catesbiana.
- Morphological study on neuropeptides in the rat spinal cord (I)
- Ontogeny of the enkephalinergic neuron system in the rat lower brain stem
- Organization of some neuropeptides in the dorsal pontine tegmentum of the rat
- Ontogeny of the substance P neuron system in the rat lower brain stem
- Distribution of substance P in the frog brain, Rana catesbiana.
- Ontogeny of the substance P(SP) neuron system in the rat forebrain and upper brain stem.
- Distribution of substance P in the fish (Carp)
- Fine Structure of Noradrenaline Nerve Terminals in the N. Tractus Spinalis Nervi Trigemini of the Rats as demonstrated by a modified Potassium Permanganate Method
- Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice
- 12. Gene expressions of bone and cartilage matrix proteins during ectopic hard tissue formation induced by BMP.
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- EFFECTS OF OPIOID PEPTIDES ON NEURONAL ACTIVITIES OF THE CNS : STUDIES USING MICROELECTROPHORETIC METHOD
- First report of a 7-year survey on ABO-incompatible kidney transplantation in Japan
- Aderenocorticotropic Hormone (ACTH) Increases the Expression of Its Own Receptor Gene
- Perpendicular Magnetic Anisotropy of TbCo Films
- Measurement of Magnetostriction of Amorphous Dy-Fe Films by Cantilever Capacitance Method
- Magnetostriction of Amorphous Gd-Fe and Tb-Fe Sputtered Films
- Partial Purification of Phytase from a Soil Isolate Bacterium, Klebsiella oxytoca MO-3
- Long-lasting Antiepileptic Effects of Levetiracetam against Epileptic Seizures in the Spontaneously Epileptic Rat (SER) : Differentiation of Levetiracetam from Conventional Antiepileptic Drugs
- Separation of Antiepileptogenic and Antiseizure Effects of Levetiracetam in the Spontaneously Epileptic Rat (SER)
- Activation by N-Acetyl-L-Aspartate of Acutely Dissociated Hippocampal Neurons in Rats via Metabotropic Glutamate Receptors
- IV F2 Is levetiracetam distinct from conventional antiepileptic drugs by antiepileptogenic properties in spontaneous epileptic rats?
- Unusual Accessory Cranial Sutures in Pediatric Head Trauma
- Incidentally Discovered Adrenocortical Adenomas Are Not Fully Nonfunctioning: lmmunohistochemical and Dispersed Adrenocortical Cell Study
- Detection of Superoxide Free Radicals in Rats with Acute Pancreatitis
- LFA-1 (CD11a/CD18) and ICAM-1 (CD54) Antibodies Attenuate Superoxide Anion Release from Polymorphonuclear Leukocytes in Rats with Experimental Acute Pancreatitis
- The Involvement and Sources of Active Oxygen in Experimentally Induced Acute Pancreatitis
- Limited Proteolysis of Silkworm Antitrypsin by Several Proteinases(Biological Chemistry)
- Transcriptional Analysis of the ostA/imp Gene Involved in Organic Solvent Sensitivity in Escherichia coli
- The Production of Recombinant APRP, an Alkaline Protease Derived from Bacillus pumilus TYO-67, by In Vitro Refolding of Pro-enzyme Fixed on a Solid Surface
- Improved Autoprocessing Efficiency of Mutant Subtilisins E with Altered Specificity by Engineering of the Pro-Region^1
- Cryoprotective Effect of the Serine-Rich Repetitive Sequence in Silk Protein Sericin^1
- Secondary Hyperparathyroidism:Pathophysiology,Histopathology,and Medical and Surgical Management
- Purification and Characterization of 0-Acetylserine Sulfhydrylase of Corynebacterium glutamicum
- Cloning and Overexpression of the Exiguobacterium sp. F42 Gene Encoding a New Short Chain Dehydrogenase, Which Catalyzes the Stereoselective Reduction of Ethyl 3-Oxo-3-(2-thienyl)propanoate to Ethyl (S)-3-Hydroxy-3-(2-thienyl)propanoate
- Enhanced Thermostability of the Single-Cys Mutant Subtilisin E under Oxidizing Conditions^1
- 2S107 Metabolism and regulation of L-cysteine in Brevibacterium flavum (Corynebacterium glutamicum)
- Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices
- POSSIBLE MECHANISM INVOLVED IN THE INHIBITORY ACTION OF U-50,488H, AN OPIOID κ AGONIST, ON GUINEA PIG HIPPOCAMPAL CA3 PYRAMIDAL NEURONS IN VITRO
- Gait analysis in an osteoarthritis patient with restoration of the hip joint space following contralateral total hip arthroplasty : a case report
- Involvement of Glutamate Receptors Within the Central Nucleus of the Amygdala in Naloxone-Precipitated Morphine Withdrawal- Induced Conditioned Place Aversion in Rats
- Apoptosis of cultured microglia by the deprivation of macrophage colony-stimulating factor
- Participation of cAMP and cAMP-dependent protein kinase in β-adrenoceptor-mediated interleukin-1β mRNA induction in cultured microglia
- TI-2 disc herniation following an en bloc cervical laminoplasty
- Image-Guided Anterior Thoracolumbar Corpectomy : A Report of Three Cases
- Phase II Trial of 5-Fluorouracil and Low-Dose Cisplatin in Patients with Squamous Cell Carcinoma of the Esophagus
- Tumor-specific Activation of Mitogen-activated Protein Kinase in Human Colorectal and Gastric Carcinoma Tissues
- Sional Transduction of GnRH Receptor in the Reproductive Tract Tumor
- Characterization of Novel Acetyltransferases Found in Budding and Fission Yeasts That Detoxify a Proline Analogue, Azetidine-2-Carboxylic Acid
- Development of Gene Delivery Systems for the ε-Poly-L-Lysine Producer, Streptomyces albulus(Genetics, Molecular Biology, and Gene Engineering)
- Overexpression and Characterization of an Aminoglycoside 6'-N-Acetyltransferase with Broad Specificity from an ε-Poly-L-lysine Producer, Streptomyces albulus IFO14147
- Cloning and Analysis of the β-Lactamase Gene from ε-Poly-L-lysine-Producing Actinomycete Streptomyces albulus IFO14147
- Effect of Proline and Arginine Metabolism on Freezing Stress of Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Effect of Gene Disruption of Succinate Dehydrogenase on Succinate Production in a Sake Yeast Strain
- Efficient Selection for Thermostable Protease in Themus thermophilus
- Engineering Subtilisin E for Enhanced Stability and Activity in Polar Organic Solvents
- Isolation and Sequence Analysis of Plasmid pNO33 in the ε-Poly-_L-Lysine-Producing Actinomycete Streptomyces albulus IFO1417
- Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain : possible involvement in the development of neuropathic pain
- Involvement of Locus Coeruleus Noradrenergic Neurons in Supraspinal Antinociception by α, β-Methylene-ATP in Rats
- Involvement of β_2-Adrenergic and μ-Opioid Receptors in Antinociception Produced by Intracerebroventricular Administration of α,β-Methylene-ATP
- Sensitization of the Adenylyl Cyclase System in Cloned κ-Opioid Receptor-Transfected Cells Following Sustained Agonist Treatment : A Chimeric Study Using G Protein α_/α_q Subunits
- Bremazocine Recognizes the Difference in Four Amino Acid Residues to Discriminate Between a Nociceptin/Orphanin FQ Receptor and Opioid Receptors
- Antinociceptive Effects of Oriental Medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh in Mice and Rats
- A Possible Vascular Malformation Origin for Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage
- Cerebral Bacterial Aneurysm and Indications for Cerebral Angiography in Infective Endocarditis
- Fenestration of the Intracranial Internal Carotid Artery : Case Report
- Neurinoma of the Oculomotor Nerve : Case Report
- Significance of Vascular Notching of Optic Nerves and Chiasm on Visual Disturbance
- S-I-13. U-Form External Decompression:Bilateral Fronto-Temporo-Parietal External Decompression
- B-49. Clinical Manifestatione and Operative Procedure of Upper Cervical Lesions-C_1・C_2 Fracture Dislocation and Atoanto-Axial Dislocation
- A-5. Clinical Manifestations and Operative Results of Frontal Head Injury
- HYDROLYTIC DEACTIVATION OF KYOTORPHIN BY THE RODENT BRAIN HOMOGENATES AND SERA
- Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
- Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
- Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice
- Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
- Conversion of the Cleavage Specificity of Subtilisin YaB on Oxidized Insulin Chains to an Elastase-like Specificity by Replacement of Glyl24 with Ala(Biochemistry & Molecular Biology)
- A Novel Metal-Activated L-Serine O-Acetyltransferase from Thermus thermophilus HB8
- Itch-associated response induced by intradermal serotonin through 5-HT_2 receptors in mice
- Different Effects of Intrathecal Neurotoxins fot serotonergic and Catecholaminergic Systems on Antinociceptive Actions of Kei-Kyo-Zoh-Soh-Oh-Shin-Bu-toh and Morphine in Rats
- Involvement of Spinal Substance P and Excitatory Amino Acids in Inflammatory Hyperalgesia in Rats
- EFFECTS OF INTRAVENTRICULARLY ADMINISTERED SEROTONIN, NORADRENALINE, DOPAMINE AND METARAMINOL ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
- EFFECTS OF SEVERAL MONOAMINE-RELATED COMPOUNDS ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
- S-4. Atlanto-Axial Dislocation : Report of thirty cases
- Molecular biology of the opioid receptors: structures, functions and distributions