EFFECTS OF SEVERAL MONOAMINE-RELATED COMPOUNDS ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
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概要
- 論文の詳細を見る
Effects of several monoamine-related compounds on the reserpine-induced spikes recorded from the medial nucleus Trapezoides (reserpine-induced Tr spikes) in rabbits were investigated. 5HTP (30-50 mg/kg, i.p.) showed marked suppression of reserpine-induced Tr spikes. Parachlorophenylalanine (PCPA) alone induced spikes similar to reserpine-induced Tr spikes after repeated doses (250 mg/kg twice daily for 3 successive days). A marked enhancement of the generation of reserpinc-induced Tr spikes was elicited, when reserpine was given to rabbits pretreated with PCPA. L-DOPA (30-50 mg/kg, i.p.) showed a slight but significant suppressive action 20 to 40 min after injection. α-methyl-p-tyrosine (α-MT) (200 mg/kg, i.p.) produced no significant change within 6 hr, but did show a marked facilitatory effect on the generation oft he spikes when reserpine was given to rabbits pretreated with α-MT. α-methyl-metatyrosine (α-M MT) (100 mg/kg, i.v.) caused a long-lasting, marked suppression. These findings suggest that both catechotamines and 5HT have a suppressive action on the generation of reserpine-induced Tr spikes.
- 社団法人 日本薬理学会の論文
著者
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TAKAGI Hiroshi
Department of Surgery II, University School of Medicine
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Takagi Hiroshi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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KIMURA Kiyoshi
Nippon Shinyaku Research Laboratories
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KIMURA Yutaka
Nippon Shinyaku Research Laboratories
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OHATA Katsuya
Nippon Shinyaku Research Laboratories
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Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
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