EFFECTS OF INTRAVENTRICULARLY ADMINISTERED SEROTONIN, NORADRENALINE, DOPAMINE AND METARAMINOL ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
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概要
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Effects of intraventricularly administered serotonin (5HT), noradrenaline (NA), dopamine (DA) and metaraminol on the reserpine-induced spikes recorded from the medial nucleus Trapezoides (Trap. m.) in rabbits were investigated. 5HT (30, 50 μg) produced marked decreases in the amplitude and discharge rate of the spikes 3 to 5 min after intraventricular administration. NA (30, 50 μg) also produced similar effects to those of 5HT, but DA at the same dosage produced no significant changes in the amplitude and discharge rate of spikes. Metaraminol, a metabolite of α-methyl-mtyrosine, produced gradual and long-lasting, potent suppression of spikes. Ninety min later, spikes were completely suppressed, and no recovery was observed within 6 hours after intraventricular administration. These results indicate that NA has a similar suppressing action to that of 5HT on the generation of the reserpine-induced spikes.
- 社団法人 日本薬理学会の論文
著者
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TAKAGI Hiroshi
Department of Surgery II, University School of Medicine
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Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Takagi Hiroshi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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KIMURA Kiyoshi
Nippon Shinyaku Research Laboratories
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KIMURA Yutaka
Nippon Shinyaku Research Laboratories
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Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
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