Two-Phase Increment of Ca2+ Uptake, Intracellular Ca2+ Concentration, and Histamine Release Following Antigen Stimulation in Mouse Bone Marrow-Derived Mast Cells (BMMC).
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概要
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The relationship between the influx of Ca<SUP>2+</SUP> into cells or cytosolic Ca<SUP>2+</SUP> concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) and the histamine release following antigen stimulation in mouse bone marrow-derived mast cells (BMMC) was examined, and the results were compared with those from human lung mast cells (HLMC) and rat peritoneal mast cells (RPMC) in some experiments. Anaphylactic histamine release from BMMC as well as HLMC, but not that from RPMC, was dependent on the extracellular Ca<SUP>2+</SUP>. When BMMC were challenged by antigen following radioactive <SUP>45</SUP>Ca<SUP>2+</SUP> addition, two phases of <SUP>45</SUP>Ca<SUP>2+</SUP> influx into the cells were observed. The first phase, which was initiated and completed within 30 sec and 2 min, respectively, after antigen treatment, appeared to be related to anaphylactic histamine release. The second influx began 30 sec subsequent to the first one and lasted for at least 2 min, and this occurred after the completion of the histamine release; So far, it is not known how this second influx participates in the intracellular event(s). On the other hand, only one sustained elevation of [Ca<SUP>2+</SUP>]<SUB>i</SUB> occurred that reached its maximum within 2 min after antigen stimulation. Following stimulation of BMMC with antigen in the absence of Ca<SUP>2+</SUP>, Ca<SUP>2+</SUP> addition 1 to 5 min later time-dependently enhanced the histamine release, although the release was deteriorated by further extension of Ca<SUP>2+</SUP> addition. In contrast, the releasability of HLMC was rapidly decreased. These results indicate that extracellular Ca<SUP>2+</SUP> not only is prerequisite for anaphylactic histamine release from BMMC, but also may modulate the release and participate in some intracellular event(s) which has yet to be focused upon.
- 公益社団法人 日本薬理学会の論文
著者
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Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Horiba Michiaki
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
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Yamamura Hideki
Department Of Anatomy Hiroshima University School Of Medicine
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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Tanaka Yoshiyuki
Department Of Biology Faculty Of Science Kobe University
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Masuda Tatsunori
Department of Pharmacology, Kyoto Pharmaceutical University
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Ohkawa Eichi
Department of Pharmacology, Kyoto Pharmaceutical University
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Kondo Shoji
Department of Pharmacology, Kyoto Pharmaceutical University
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KONDO Shoji
Department of Hygiene, Tohoku University
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