Acquired Nasal Hyperresponsiveness Aggravates Antigen-Induced Rhinitis in the Guinea Pig
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概要
- 論文の詳細を見る
Whether a state of nasal hyperresponsiveness influences antigen-induced biphasic nasal blockage and sneezing were examined using a guinea pig model of allergic rhinitis. Sensitized animals were challenged with an antigen, Japanese cedar pollen, once every week. Before the 13th challenge, the animals were randomly divided into 2 groups, and then the 13th challenge was performed (Groups A-0 and B-0). The 14th challenge was done on day 2 (Group A-2) and on day 7 (Group B-7) after the 13th challenge, on which nasal hyperresponsiveness was present and absent, respectively. Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0. An anti-histaminic, mepyramine, inhibited sneezing but not the biphasic nasal blockage in Group B-7. A cysteinyl leukotriene (CysLT) antagonist, pranlukast, suppressed the late nasal blockage but not the early blockage and sneezing in Group B-7. In contrast, in Group A-2, mepyramine significantly attenuated not only sneezing but also the early nasal blockage. Pranlukast significantly inhibited both nasal blockage and sneezing in Group A-2. In conclusion, nasal hyperresponsiveness aggravated the antigen-induced nasal responses, to which histamine and CysLTs considerably contributed.
- 社団法人 日本薬理学会の論文
- 2003-12-01
著者
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TAKENAKA Hiroshi
Department of Earth and Planetary Sciences, Kyushu University
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Sugahara Yazuyuki
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Mizutani Nobuaki
Department of Pharmacology, Kobe Pharmaceutical University, Japan
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NABE Takeshi
Department of Pharmacology, Kyoto Pharmaceutical University
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KOHNO Shigekatsu
Department of Pharmacology, Kyoto Pharmaceutical University
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Takenaka Hiroshi
Department Of Otolaryngology Osaka Medical College
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Takenaka Hiroshi
Department Of Otorhinolaryngology Osaka Medical College
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
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Takenaka H
Kyushu Univ.
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Takenaka Hiroshi
Department Of Earth And Planetary Sciences Kyushu University
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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Mizutani Nobuaki
Department Of Pharmacology Kobe Pharmaceutical University
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Takenaka Hiroshi
Department Of Chemistry Faculty Of Science Osaka City University
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Nabe T
Department Of Pharmacology Kyoto Pharmaceutical University
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