Arachidonate 5-Lipoxygenase and Cyclooxygenase Metabolites From Guinea Pig Eosinophils and Macrophages
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概要
- 論文の詳細を見る
To investigate the cellular sources of arachidonate metabolites during asthma, in vitro productions of thromboxane(TX)B2, prostaglandin(PG)D2, leukotriene(LT)B4 and cysteinyl(Cys)LTs from guinea pig eosinophils and macrophages simultaneously stimulated with the Ca ionophore A23187 were investigated.Eosinophils produced high levels of LTB4 and TXB2 and relatively low levels of CysLTs and PGD2.Although macrophages released abundant TXB2 and a little PGD2, 5−lipoxygenase metabolites were below detectable levels.In conclusion, eosinophils produced both cyclooxygenase and 5−lipoxygenase metabolites, while arachidonate metabolism in the macrophages was almost completely inclined toward the cyclooxygenase pathway.
- 社団法人 日本薬理学会の論文
- 2000-07-01
著者
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KOHNO Shigekatsu
Department of Pharmacology, Kyoto Pharmaceutical University
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
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MIURA Makoto
Department of Agro-bioscience, Iwate University
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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KAMIKI Toshihisa
Department of Pharmacology, Kyoto Pharmaceutical University
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Kohno Shigekatsu
Department Of Pharmacology Kyoto Pharmaceutical University
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Kamiki Toshihisa
Department Of Pharmacology Kyoto Pharmaceutical University
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Miura Makoto
Department Of Pharmacology Kyoto Pharmaceutical University
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