Pulmonary Emphysema Induced by Cigarette Smoke Solution and Lipopolysaccharide in Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Exposure of animals to cigarette smoke for longer than 3 months leads to the development of chronic obstructive pulmonary disease (COPD) showing pulmonary emphysema. We attempted to create a COPD model with emphysema that could be established in a shorter period of time. Guinea pigs were intratracheally treated once a day on days 0—3, 5—8, 10—13 and 15—18 with a cigarette smoke solution (CSS), which was prepared by bubbling a stream of smoke into saline. Additionally, lipopolysaccharide (LPS) was administered intratracheally as an exacerbation factor on days 4, 9 and 14. By day 19, there was a gradual elevation of specific airway resistance (sRaw). In addition, both residual volume and functional residual capacity were found to be significantly higher on day 19. In the lungs, there was a marked increase in leukocytes, especially neutrophils. Histologically, we observed epithelial hyperplasia and emphysema. On the other hand, daily oral administration of theophylline during the administration of CSS and LPS suppressed the sRaw increase and the epithelial hyperplasia, but not other functional structural changes. In conclusion, we established an experimental COPD model in guinea pigs by using intratracheal instillations of CSS and LPS over a considerably shorter term than has been reported for other models.
- 日本薬学会の論文
著者
-
Takahashi Maki
Sugi Institute of Biological Science Co., Ltd.
-
Fuchikami Jun-ichi
Sugi Institute of Biological Science Co., Ltd.
-
Takahashi Maki
スギ生物科学研究所
-
Mizutani Nobuaki
Department of Pharmacology, Kobe Pharmaceutical University, Japan
-
Yoshino Shin
Department of Pharmacology, Kobe Pharmaceutical University, Japan
-
Yoshino Shin
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
-
NABE Takeshi
Department of Pharmacology, Kyoto Pharmaceutical University
-
KOHNO Shigekatsu
Department of Pharmacology, Kyoto Pharmaceutical University
-
Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
-
Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
-
Mizutani Nobuaki
Department Of Pharmacology Kobe Pharmaceutical University
-
Fuchikami Jun-ichi
Sugi Institute Of Biological Science Co. Ltd.
-
Takahashi Maki
Sugi Institute Of Biological Science Co. Ltd.
関連論文
- A Cardiac Rhabdomyoma in a Guinea Pig
- Seroprevalence of Antibodies to Chlamydia spp.in Human Immunodeficiency Virus-Infected Subjects in Japan
- Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody—Induced Arthritis
- Reproducible Biphasic Cutaneous Edema Induced by Topical and Repeated Application of Antigen in Sensitized Mice
- Comparative studies on nebulizers fro antigen inhalation in experimental asthma
- A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs
- Repeated Antigen Inhalation-Induced Reproducible Early and Late Asthma in Guinea Pigs
- Sephadex G-200-Induced Eosinophil Infiltration into Airways in Non-sensitized and Sensitized Guinea Pigs, and Responsiveness of the Calls to Stimuli In Vitro
- Antiallergic Effects of Mequitazine. II. : In Vivo Experiments.
- Antiallergic Effects of Mequitazine. I. : In Vitro Experiments.
- Delayed Type Allergic Itch-Associated Response Induced by Toluene-2,4-diisocyanate in Hairless Mice
- Anti-estrogenic Activity of Diesel Exhaust Particles
- Markedly Increased Nasal Blockage by Intranasal Leukotriene D_4 in an Experimental Allergic Rhinitis Model: Contribution of Dilated Mucosal Blood Vessels
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Pulmonary Emphysema Induced by Cigarette Smoke Solution and Lipopolysaccharide in Guinea Pigs
- Absence of Nasal Blockage in a Japanese Cedar Pollen-Induced Allergic Rhinitis Model Mouse
- Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs
- Effects of Multiple Dexamethasone Treatments on Aggravation of Allergic Conjunctivitis Associated with Mast Cell Hyperplasia(Pharmacology)
- Polycyclic Aromatic Hydrocarbons Aggravate Antigen-Induced Nasal Blockage in Experimental Allergic Rhinitis
- Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis
- Development of Numerous Nerve Fibers in the Epidermis of Hairless Mice With Atopic Dermatitis-Like Pruritic Skin Inflammation
- Detection of New Antigenic Proteins in Japanese Cedar Pollen(Pharmacology)
- Effect of Oral Immunotherapy on Nasal Blockage in Experimental Allergic Rhinitis
- Acquired Nasal Hyperresponsiveness Aggravates Antigen-Induced Rhinitis in the Guinea Pig
- Multiple Cedar Pollen Challenge Diminishes Involvement of Histamine in Allergic Conjunctivitis of Guinea Pigs (Highlighted paper selected by Editor-in-chief)(Pharmacology)
- Comparison of Cedar Pollen - Induced Allergic Rhinitis in Passively and Actively Sensitized Guinea Pigs
- A Tiaramide Derivative, 5-Chloro-3-(4-hydroxypiperadinocarbonylmethyl) benzothiazoline-2-one (HPR-611), a Potent Inhibitor of Anaphylactic Chemical Mediator Release-A Distinctive Feature from Disodium Cromoglycate
- Intratracheal Sensitization/Challenge-Induced Biphasic Asthmatic Response and Airway Hyperresponsiveness in Guinea Pigs
- INDUCTION OF A DELAYED TYPE HYPERSENSITIVITY TO CARRAGEENIN IN MICE
- Influence of anti-inflammatory and anti-rheumatic drugs on the Th1/Th2 immune system.(GENERAL SESSION BY POSTER PRESENTATION)(IMMUNE AND ALLERGIC SYSTEM)
- Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice
- Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody-Induced Arthritis
- Atopic dermatitis model of itching behavior in hairless mice
- Repeated Antigen Inhalations Alter Chemical Mediators That Cause Asthmatic Obstruction in Guinea Pigs
- Arachidonate 5-Lipoxygenase and Cyclooxygenase Metabolites From Guinea Pig Eosinophils and Macrophages
- Involvement of kinins and tachykinins in the development of nasal hyperresponsiveness in a guinea pig pollinosis model
- Complete Dependence on CD4^+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice
- A Cardiac Rhabdomyoma in a Guinea Pig
- Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin
- Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma
- Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
- Effect of oxitropium bromide (Ba253) on increased airway resistance induced by various agonists and antigen in the guinea pig.
- Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells.
- Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
- Dimaprit, a Histamine H2-Agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release Is Restored by Thioperamide (H3-Antagonist), but Not by Cimetidine (H2-Antagonist).
- Significant Role of Peptide Leukotrienes (p-LTs) in the Antigen-Induced Contractions of Human and Guinea Pig Lung Parenchymas and Bronchi or Tracheas In Vitro.
- Two-Phase Increment of Ca2+ Uptake, Intracellular Ca2+ Concentration, and Histamine Release Following Antigen Stimulation in Mouse Bone Marrow-Derived Mast Cells (BMMC).
- Important Role of Peptide Leukotrienes (p-LTs) in the Resting Tonus of Isolated Human Bronchi.
- Effect of oexitropium bromide (Ba253) on isolated respiratory smooth muscle and release of chemical mediators from passively sensitized lung fragments.
- Studies on toluene diisocyanate (TDI)-induced delayed type hypersensitivity.
- Receptor binding profile of quinupramine, a new tricyclic antidepressant.
- Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.
- Binding characteristics of (3H)quinupramine to rat brain membrane fractions.
- MCI-826 Is a Potent and Selective Antagonist of Peptide Leukotrienes(p-LTs) and Has Characteristics Distinctive from Those of FPL 55712.