Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma
スポンサーリンク
概要
- 論文の詳細を見る
Airway remodeling, pathological changes in the lung structure, is a characteristic feature of chronic asthma. The changes include bronchial epithelial hyperplasia and hypertrophy, excess production of mucus, and fibroblast proliferation in the lung. On the other hand, it has been known that both nitric oxide and superoxide anion are increased in exhaled air of asthmatic patients. These molecules react with each other forming a powerful oxidant, peroxynitrite. In this study, effect of a peroxynitrite scavenger, a metalloporphyrin compound, [tetrakis(4-carboxylatophenyl)porphyrinato]manganese(III) (MnTBAP) on multiple antigen challenge-induced airway remodeling was evaluated in mice. When sensitized BALB/c mice were intratracheally challenged with an antigen, ovalbumin, for 3 times, bronchial epithelial thickening and mucus accumulation in the epithelium were histologically observed. Daily treatment with MnTBAP (3 and 10 mg/kg/time/twice a day, i.p.) dose-dependently suppressed both the epithelial thickening and mucus accumulation in the epithelium. On the other hand, TUNEL staining revealed that the multiple antigen challenges increased the number of apoptotic cells in the bronchial epithelium. The increase in apoptotic cells was also effectively suppressed by the treatment with MnTBAP. Taken together, it was suggested that peroxynitrite could be involved in the formation of epithelial hyperplasia associated with the mucus accumulation through induction of apoptosis of the epithelial cells. Thus, peroxynitrite can be a target molecule for development of new pharmacotherapy for asthma.
著者
-
Fujii Masanori
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
-
Yasui Hiroyuki
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
-
Ishihara Keiichi
Department Of Biochemistry Kyoto Pharmaceutical University
-
Akiba Satoshi
Department Of Pathological Biochemistry Kyoto Pharmaceutical University
-
Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
-
Fujii Masanori
Department of Pharmacology, Kyoto Pharmaceutical University
-
Cao Yang
Department of Pharmacology, Kyoto Pharmaceutical University
関連論文
- 赤痢アメーバ原虫に対するトリフルオロメチオニン誘導体の有効性(研究論文紹介)
- Effect of Carperitide on Plasma Adiponectin Levels in Acute Decompensated Heart Failure Patients With Diabetes Mellitus
- Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension
- Whole-Body Periodic Acceleration Enhances Brachial Endothelial Function
- Dose-Dependent Prognostic Effect of Carvedilol in Patients With Chronic Heart Failure : Special Reference to Ranscardiac Gradient of Norepinephrine
- OE-219 Role of Bradykinin and Chymase in Cardiorenal Function under Chronic ACE Inhibition in Heart Failure(OE37,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-306 ACE and Chymase Inhibition Prevents the Cardiac Remodeling Process Interacting with Cardiac Endothelin System in Heart Failure.(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- Cardiac Mast Cell Chymase Plays a Significant Role in the Progression of Cardiac Remodeling via Collagen Accumulation(Inflammatory Heart Disease-Update and Future Perspective-, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
- Effect of Carvedilol on Plasma Adiponectin Concentration in Patients With Chronic Heart Failure : Reply
- Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension
- Effect of Carvedilol on Plasma Adiponectin Concentration in Patients With Chronic Heart Failure
- PJ-721 Low Incidence of Aldosterone Breakthrough during Efonidipine Treatment in Patients with Essential Hypertension(PJ121,Hypertension, Clinical 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-641 Comparison of Serum Levels of Cardiac Tropnin I and T in Patients with Chronic Heart Failure(PJ108,Heart Failure (Laboratory/Biomarkers) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-371 Effect of Carperitide on Plasma Adiponectin Level in Heart Failure Patients with Diabetes Mellitus(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-300 Effect of ACE Inhibitors or ARB on Transcardiac Gradient of Norepinephrine in Patients with Chronic Heart Failure(PJ051,Autonomic Nervous System (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Delayed Type Allergic Itch-Associated Response Induced by Toluene-2,4-diisocyanate in Hairless Mice
- OJ-245 Effect of Carvedilol on Plasma Adiponectin Level in Patients with Chronic Heart Failure(OJ41,Heart Failure (Treatment) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-244 Effect of Carvedilol on Transcardiac Gradient of Norepinephrine and Prognosis in Patients with Chronic Heart Failure(OJ41,Heart Failure (Treatment) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- FRS-025 Comparison with Serum Cortisol Level and Plasma Aldosterone Level as a Predictor of Cardiac Event in Patients with Heart Failure(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of T
- 5 Transcardiac Increase in Norepinephrine and Prognosis in Patients with Chronic Heart Failure(Biomarkers, Genetic Polymorphism, and Risk Estimation,Symposium 1 (SY-01) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure : Comparison With Enalapril
- Impact of Oxidative Stress on Plasma Adiponectin in Patients With Chronic Heart Failure
- PJ-513 Effect of Atrial Natriuretic peptide on Adiponectin in Patients with Heart Failure(Heart failure, clinical(18)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-512 Impact of Oxidative Stress on Plasma Adiponectin in Patients with Heart Failure(Heart failure, clinical(18)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension
- バナジルーハロゲン置換ピコリン酸錯体のインスリン様作用
- OE-353 Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity in Patients with Chronic Heart Failure : Comparison with Enalapril(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
- Comparison of Active Renin Concentration and Plasma Renin Activity as a Prognostic Predictor in Patients With Heart Failure
- Proteome Analysis Reveals the Significant Alternations of Cardiac Small Heat Shock Proteins Expression in Heart Failure (Heart Failure, Basic 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Chronic NADPH Oxidase Inhibiton Improves Cardiac Function through the Suppression of Oxidative Stress in Heart Failure(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Contribution of Vascular NAD(P)H Oxidase to Endothelial Dysfunction in Heart Failure and the Therapeutic Effects of HMG-CoA Reductase Inhibitor
- PJ-224 The Activity and Expression of Myocardial NADPH Oxidase Are Increased in Heart Failure.(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
- OJ-440 Proteome analysis of myocardial protein expression in heart failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
- Neurohumoral Effects of Long Term Infusion of hANP in Patients with Severe Congestive Heart Failure
- Effect of HSP47 on Prolyl 4-Hydroxylation of Collagen Model Peptides
- A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)
- Absence of Nasal Blockage in a Japanese Cedar Pollen-Induced Allergic Rhinitis Model Mouse
- Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs
- Effects of Multiple Dexamethasone Treatments on Aggravation of Allergic Conjunctivitis Associated with Mast Cell Hyperplasia(Pharmacology)
- Polycyclic Aromatic Hydrocarbons Aggravate Antigen-Induced Nasal Blockage in Experimental Allergic Rhinitis
- Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis
- Development of Numerous Nerve Fibers in the Epidermis of Hairless Mice With Atopic Dermatitis-Like Pruritic Skin Inflammation
- Detection of New Antigenic Proteins in Japanese Cedar Pollen(Pharmacology)
- Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure
- Direct Comparison of Brain Natriuretic Peptide (BNP) and N-Terminal Pro-BNP Secretion and Extent of Coronary Artery Stenosis in Patients With Stable Coronary Artery Disease
- PJ-634 Plasma High-Molecular Weight Adiponectin in Patients with Chronic Heart Failure(Heart failure, clinical-17, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-633 Possible Contribution of Oxidative Stress and BNP on the Elevation of Adiponectin in Patients with Chronic Heart Failure(Heart failure, clinical-17, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-542 Comparison of Transcardiac Increase of BNP and N-terminal pro BNP in Patients with Coronary Artery Disease(Neurohumoral factors-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-488 Direct Comparison of Transcardiac Difference of Brain Natriuretic Peptide and N-terminal pro BNP in Patients with Chronic Heart Failure(Heart failure, clinical-13, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-023 Simvastatin Improves Cardiac Sympathetic Nerve Activity in Patients with Heart Failure(Heart failure, clinical-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Oxovanadium(IV)-Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4-)
- Merallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration
- A New Determination Method of Nitric Oxide (NO) with a NO-selective Electrode Demonstrated by the Kinetic Analysis of NO Generation and Decomposition
- Transcardiac Gradient of Plasma Heart-Type Fatty Acid Binding Protein as a Maker of Myocardial Injury in Patients with Dilated Cardiomyopathy
- Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
- Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method(Analytical Biochemistry)
- P-12 NATURAL PRODUCTS SYNTHESIS FEATURED BY SEQUENCIAL OLEFIN METATHESIS
- PJ-121 Long-term Clinical Variation of Brain Natriuretic Peptide (BNP) and N-terminal Pro-BNP (NT-proBNP) in Patients with Stable Chronic Heart Failure(Heart failure, clinical(13)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japan
- OJ-198 Atorvastatin Improves Cardiac Sympathetic Nerve Activity in Patients with Heart Failure(Heart failure, clinical(06)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-405 Proteome Analysis Reveals the Therapeutic Effects of Carvedilol on Myocardial Protein Expression in Heart Failure(Heart failure, basic-5 (M) PJ68,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- OJ-050 Comparative Effect of Metoprolol and Carvedilol on Myocardial Oxidative Stress in Patients with Chronic Heart Failure(Heart failure, clinical-2 (M) OJ9,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- Slightly Renal Dysfunction Influences on the Plsama N terminal proBNP Level in Patient with Heart Failure(Heart Failure, Clinical 13 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Endogenous Bradykinin Suppresses Myocardial Fibrosis through the Cardiac Generated Endothelin System under Chronic ACE Inhibition in Heart Failure
- A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(l-oxy-2-pyridinethiolato)oxovanalum(IV)with VO(S_2O_2) Coordination Mode
- Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations
- Plasma NT-proBNP as a More Reliable Biomarker of Endogenous Cardiac Natriuretic Peptides Than BNP During Carperitide Infusion
- A New Type of Orally Active Insulin-mimetic Vanadyl-porphyrin Complex : meso-Tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV)
- Determination of trace element concentrations in ancient rices (red and black rices) and a present-day rice (Koshihikari) : Relationship among the trace element concentrations, species, harvest site and rice parts
- Construction of Nonadjacent Stereocenters Containing a Trifluoromethylated Carbon by Organocatalyzed Michael Addition of β-Ketoesters to 2-(Trifluoromethyl)acrylate
- Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
- Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
- Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells
- Biological Variation of Brain Natriuretic Peptide and Cardiac Events in Stable Outpatients With Nonischemic Chronic Heart Failure
- Prediction of Mortality by High-Sensitivity C-Reactive Protein and Brain Natriuretic Peptide in Patients With Dilated Cardiomyopathy
- PJ-782 Plasma N-terminal proBNP Level is More Sensitive Marker of Myocardial Ischemia Than BNP(Neurohumoral factors-3 (H) PJ137,Poster Session (Japanese),Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice
- PJ-062 Carperitide and Renal Function in Patients with Chronic Heart Failure(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-162 Myocardial Ischemia Itself Increases the Secretion of N-terminal proBNP from the Heart Independent of Hemodynamic Overload(Chronic coronary heart disease/Remodeling-2 (IHD) OJ27,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
- OJ-108 Prognostic Value of Combination of Serum Uric Acid and Brain Natriuretic Peptide in Patients with Chronic Heart Failure(Heart failure, clinical-4 (M) OJ18,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese C
- OJ-107 Plasma Active Renin Concentration is an Independent Prognostic Predictor in Patients with Chronic Heart Failure(Heart failure, clinical-4 (M) OJ18,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- Atopic dermatitis model of itching behavior in hairless mice
- Prognostic Role of High-Sensitivity Cardiac Troponin T in Patients With Nonischemic Dilated Cardiomyopathy
- Oxidized Low-Density Lipoprotein As a Useful Biochemical Marker of Oxidative Stress in Patients with Congestive Heart Failure
- Xanthine Oxidase Is Activated in the Heart in Patients with Congestive Heart Failure
- C-Reactive Protein Is Secreted from the Heart in Patients with Acute Coronary Syndrome
- Transcardiac Gradient of Aldosterone before and after Spironolactone in Patients with Congestive Heart Failure
- Plasma Oxidized Low-Density Lipoprotein Decreased with Improvement of Congestive Heart Failure
- Bradykinin Improves Renal Function under Chronic Angiotensin-Converting Enzyme Inhibition in Heart Failure
- TNF α in the Heart but not Peripheral Level Plays a Significant Role in LV Remodeling in Patients with DCM
- OE-122 A Marker of Downregulation of Endogenous Natriuretic Peptide is an Independent Prognostic Predictor in Patients with Chronic Heart Failure(Heart failure, clinical(02)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese
- OE-066 Plasma Level of Cardiotrophin-1 as a Prognostic Predictor in Patients with Chronic Heart Failure(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-063 Cardiac Natriuretic Peptide as a Prognostic Biomarker of Heart Failure(Prognostic Biomarkers of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Carperitide (ANP) Increases Plasma Adiponectin in Patients with Heart Failure(Peptide Hormones in Cardiovascular Diseases,Topic 4 (TP-4) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship Between Biological Variation in B-Type Natriuretic Peptide and Plasma Renin Concentration in Stable Outpatients With Dilated Cardiomyopathy
- Effect of Atorvastatin vs. Rosuvastatin on Cardiac Sympathetic Nerve Activity in Non-Diabetic Patients With Dilated Cardiomyopathy
- Complete Dependence on CD4^+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice
- Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin
- Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma