Effect of Carvedilol on Plasma Adiponectin Concentration in Patients With Chronic Heart Failure

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概要

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• Background: Patients with a high plasma adiponectin have a poor prognosis in chronic heart failure (CHF). Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are reported to increase the plasma adiponectin concentration, but the effect of β-blockers on plasma adiponectin in patients with CHF remains unknown. Methods and Results: Blood samples were collected at before and 6 months after administration of carvedilol in 44 CHF patients. The hemodynamic parameters, echocardiography, plasma concentrations of brain natriuretic peptide (BNP), norepinephrine and adiponectin were measured. Six months after treatment, there were significantly decreased plasma concentrations of adiponectin (15.8 ±1.4 to 11.0 ±1.1 μg/ml, P<0.0001), BNP and norepinephrine and increased left ventricular ejection fraction (LVEF). On stepwise multivariable analyses, a higher plasma adiponectin concentration before treatment (rs=-0.561, P<0.0001) was a significant independent predictor of a greater decrease in adiponectin concentration and the decrease in plasma adiponectin concentration was significantly correlated with the improvement of LVEF (r=-0.561, P<0.0001). Conclusions: These findings indicate that carvedilol decreases plasma adiponectin concentration and that the decrease in plasma adiponectin is associated with the improvement of LVEF after treatment with carvedilol in CHF patients. (Circ J 2009; 73: 1067-1073)

• 社団法人　日本循環器学会の論文
• 2009-05-20

著者

• YAMAJI Masayuki

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• TSUTAMOTO Takayoshi

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• TANAKA Toshinari

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• KAWAHARA Chiho

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• NISHIYAMA Keizo

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• YAMAMOTO Takashi

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• FUJII Masanori

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• HORIE Minoru

  Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Fujii Masanori

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• MITAMURA Hideo

  Saiseikai Central Hospital

• Yamamoto Takashi

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Mori H

  Department Of Bioscience Department Of Cardiovascular Surgery

• Matsubara H

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Mori Hidezo

  岩手医科大学 物理学科

• Mori H

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Horiba Mitsuru

  名古屋大学環境医学研究所 循環器学

• Tsutamoto Takayoshi

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Tanaka Toshinari

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• MATSUBARA Hiromi

  Cardiovascular Medicine Okayama University Medical School

• Horie Minoru

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Horie Minoru

  Department Of Cardiovascular-respiratory Medicine Shiga University Of Medical Science

• Horie Minoru

  Department Of Cardiopulmonary Medicine Shiga University Of Medical Science

• Yamaji Masayuki

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Kawahara Chiho

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Nishiyama Keizo

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Tsutamoto Takayoshi

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Mori Hidezo

  Department Of Physiology Tokai University School Of Medicine

• Hone Minoru

  Department Of Cardiovascular And Respiratory Medicine Siga University Of Medical Science

• Tsutamoto Takayoshi

  Department Of Internal Medicine Shiga University Of Medical Science

• Tsutamoto Takayoshi

  First Department Of Internal Medicine Shiga University Of Medical Science

• Hojho Mayumi

  Department Of Circulation Research Institute Of Environmental Medicine

• Yabe Takahiro

  Department Of Cardiology Shiga University Of Medical Science

• Yamamoto Takashi

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Kawahara Chiho

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Fujii Masanori

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Mikohchi Hiroshi

  Division Of Cardiology National Hospital Organization Okayama Medical Center

• Yamaji Masayuki

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Tsutui Takashi

  First Department Of Internal Medicine Shiga University Of Medical Science

• Nishiyama Keizo

  Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Mori Hidezo

  Department Of Bioscience National Cardiovascular Center Research Institute

• Matsubara Hiromi

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

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