Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
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概要
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Effects of 12 compounds including 5-lipoxygenase (5-LO) inhibitors and antiallergic drugs on the activity of 5-LO from the polymorphonuclear leukocytes (PMN) of guinea pigs, rats, rabbits, monkeys and humans were examined. The 5-LO activity was inhibited by the drugs according to the following orders of efficacy: Guinea pig 5-LO, 5-HDHDMF>TZI-2721>NDGA>AA861>FPL55712>isoproterenol; rat 5-LO, 5-HDHDMF>AA861>TZI-2721>NDGA>FPL55712>KP-136>MCI-826>benoxaprofen; and rabbit 5-LO, 5-HDHDMF>TZI-2721>NDGA> AA861>FPL55712>KP-136>MCI-826. The 5-LO activity from the rhesus monkey was dose-dependently inhibited by only 3 compounds, 5-HDHDMF> NDGA>TZI-2721, in this order, but the other compounds, except for AA861, did not show any effect on this activity. In humans, 5-LO activity was inhibited in the following order: TZI-2721>5-HDHDMF>NDGA>AA861>FPL55712. From these results, it was strongly suggested that there is a species difference of this enzyme in its sensitivity to drugs.
- 公益社団法人 日本薬理学会の論文
著者
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Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Obata Noriko
Department Of Chemical Biology Osaka City University Medical School
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Yamamura Hideki
Department Of Anatomy Hiroshima University School Of Medicine
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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OKUMURA MAKOTO
Department of Internal Medicine, Fukuoka University School of Medicine
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