Bartters Syndrome: Effect of Indomethacin on Prostaglandins, Urinary Kallikrein, Renin-Angiotensin-Aldosterone System, and the Response to Angiotensin II Antagonist
スポンサーリンク
概要
- 論文の詳細を見る
In two patients with Bartters syndrome, significant increases in serum immunoreactive prostaglandin E like-material (iPGE) and urinary kallikrein excretion were observed during the control period. Urinary PGE excretion was not always increased as serum iPGE. After an administration of indomethacin, an inhibitor of prostaglandins (PGs) synthetase, their clinical symptoms, hyperactivity of renin-angiotensinaldosterone (R-A-A) system and resistence to the pressor effects of angiotensin II and norepinephrine were apparently eliminated, but hypokalemia was not corrected completely. Indomethacin caused a remarkable decline in urinary kallikrein excretion and in serum and urinary PGs values. Spironolactone also produced a significant fall in urinary kallikrein excretion in spite of an extreme increase in the R-A-A system activity. However, spironolactone did not suppress the urinary PGE excretion. After an administration of aminoglutethimide, the urinary kallikrein excretion decreased gradually, followed by a decline in aldosterone production.Short-term administration of aspirin, ibuprofen, aminoglutethimide and dexamethasone did not improve hypokalemia despite the normalization of aldosterone production.<BR>An angiotensin II antagonist, [Sar<SUP>1</SUP>, Ile<SUP>8</SUP>] angiotensin II, lowered the blood pressure of hyperreninemic patients. After indomethacin, a significant improvement in blood pressure response to this antagonist was observed. These results indicate that angiotenin II receptors of arteriolar smooth muscle in patients with Bartters syndrome are still responsive to endogenous angiotensin II, andthat the R-A-A system plays a considerable role in the regulation of blood pressure. Moreover, our observations suggest that a more “proximal” cause of Bartters syndrome is renal potassium wasting i. e., hypokalemia which causes an inappropriate production of PGs in the kidney and vascular walls, resulting in vasocontrictor insensitivity and hyperactivity of the R-A-A system. Likewise, it appears that hyperactivity of the renal kallikrein-kinin system does not stimulate the production of PGs in this syndrome, but rather is secondary to increased PGs synthesis
- 社団法人 日本内分泌学会の論文
著者
-
Sasaki Haruka
Division Of Endocrine And Metabolic Medicine Chikushi Hospital Fukuoka University
-
ABE KEISHI
Department of Internal Medicine, Tohoku University School of Medicine
-
Abe Keishi
Department Of Internal Medicine Tohoku University School Of Medicine
-
Sasaki Haruka
Department Of Internal Medicine Chikushi Hospital Fukuoka University
-
Asano Takashi
Department Of Electronic Science And Engineering Kyoto University
-
KAWASAKI TERUKAZU
Department of Internal Medicine, Faculty of Medicine, Kyushu University
-
OKUMURA MAKOTO
Department of Internal Medicine, Fukuoka University School of Medicine
-
ARAKAWA KIKUKO
Department of Internal Medicine, Fukuoka University School of Medicine
-
Abe Keishi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Asano Takashi
Department Of Child Neurology Okayama University Medical School
-
SASAKI HARUKA
Department of Internal Medicine, Fukuoka University School of Medicine
関連論文
- Implication of Endogenous Prostaglandin System in the Antihypertensive Effect of Captopril,SQ14225, in Low Renin Hypertension : IX Conference on the Pathogenesis of Hypertension
- THE ROLE OF RENAL PROSTAGLANDIN E AND KALLIKREIN IN PATHOGENESIS OF ESSENTIAL HYPERTENSION
- Studies on Renomedullary Prostaglandin and Renal Kallikrein-Kinin System in Hypertension
- SIXTY CASES OF RENOVASCULAR HYPERTENSION : THE RESULTS OF SURGICAL TREATMENT : (Part III)
- Renoprotective Effect of Angiotensin-Converting Enzyme Inhibitor Combined with α_1-Adrenergic Antagonist in Spontaneously Hypertensive Rats with Renal Ablation
- -P103-THE AUGMENTED BLOOD PRESSURE RESPONSE TO CHRONIC ANGIOTENSIN II (ANG II) INFUSION IN PARTIALLY NEPHRECTOMIZED RATS : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PLASMA RENIN ACTIVITY IN ESSENTIAL HYPERTENSION, WITH SPECIAL REFERENCE TO ITS CHANGES UNDER THE INFLUENCE OF SPIRONOLACTONE AND PROPRANOLOL : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- レドックス指示薬を用いた着床前マウス初期胚生存性の定量化の試み
- The Relationships of Testosterone, Estradiol, Dehydroepiandrosterone-sulfate and Sex Hormone-binding Globulin to Lipid and Glucose Metabolism in Healthy Men
- Ambulatory Blood Pressure Monitoring in Evaluating the Prevalence of Hypertension in Adults in Ohasama, a Rural Japanese Community
- The prevalence of diabetes mellitus and impaired fasting glucose/glycaemia (IFG) in suburban Katmandu : Ethnic aspect of a community-based study of native Nepalese and Tibetan immigrants during the democratic movements in 1990
- In Situ Observation of Aluminothermic Reduction of MgO with High Temperature Optical Microscope
- Green Photoluminescence from GaInN Photonic Crystals
- The Prevalence of Type 2 Diabetes Mellitus and Fasting Impaired Glucose (IFG) in Nepal : Ethnicity and Lifestyle Aspects of a Community-Based Cross-Sectional Tibetan Buddhist Monastery Study in 1990
- Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation
- RENIN-ANGIOTENSIN SYSTEM IN HUMAN HYPERTENSION DUE TO SEGMENTAL RENAL ISCHEMIA
- Studies on Plasma Renin Activity in Patients with Renovascular Hypertension
- Clinical Research : Utility of the Scalp-Recorded Ictal EEG in Childhood Epilepsy
- Cutoff and Target Values for Intra-Abdominal Fat Area for Prevention of Metabolic Disorders in Pre- and Post-Menopausal Obese Women Before and After Weight Reduction
- P-260 The Study on Camptothecin Transporter in Ophiorrhiza pumila
- Direct Fabrication of Photonic Crystal on Glass Substrate by Nanoimprint Lithography
- Optical and Electrical Characteristics of Organic Light-Emitting Diodes with Two-Dimensional Photonic Crystals in Organic/Electrode Layers
- High-performance liquid chromatographic measurements of urinary hydroxycarboxylic acids as an index of the metabolic control in non-insulin-dependent diabetic patients
- Thin-layer chromatography and high-performance liquid chromatography for the assay of fatty acid compositions of individual phospholipids in platelets from non-insulin-dependent diabetes mellitus patients : effect of eicosapentaenoic acid ethyl ester admi
- Treatment of Advanced Hypertension : Choice of the Effective Antihypertensive Drugs using Angiotensin II Antagonist : Pathophysiology of Hypertension and its Relation to the Choice of Antihypertensive Treatment
- Clinical Aspect of Aortitis Syndrome with Special Reference to the Relation between Prognosis and Hypertension : SYMPOSIUM ON CLINICAL PROBLEMS IN AORTIC DISEASES
- Enhancement of Absorption Magnitude of Short-Wavelength Intersubband Transition in InGaAs/AlAs Quantum Wells
- Nearinfrared Intersubband Transitions in InGaAs/AlAs Quantum Wells on GaAs Substrate
- Effect of Lime Particle Size on Melting Behavior of Lime-containing Flux
- On-the-Fly Wavelength Conversion of Photons by Dynamic Control of Photonic Waveguides
- Malignant Hypertension and Microangiopathic Hemolytic Anemia
- Mechanical evaluation of debilitated tibia diaphysis in rats during the growth period : Combination therapy with high-calcium diet and grape seed proanthocyanidin extract
- Familial Bilateral Pheochromocytoma with Medullary Carcinoma of the Thyroid : The Second Kindred of Familial Pheochromocytoma in Japan
- Bartters Syndrome: Effect of Indomethacin on Prostaglandins, Urinary Kallikrein, Renin-Angiotensin-Aldosterone System, and the Response to Angiotensin II Antagonist
- Insulin Delivery Rate in Response to Glucose Infusion in Normal and Diabetic Subjects
- Partial Seizures in West Syndrome
- Movement of the Condyle Point and Incisal Point during Exercise
- Highly Effective In-Plane Channel-Drop Filters in Two-Dimensional Heterostructure Photonic-Crystal Slab
- Improved Power Conversion Efficiency of Organic Photovoltaic Cell Fabricated by Electrospray Deposition Method by Mixing Different Solvents (Special Issue : Solid State Devices and Materials (1))
- Relaxation Time of Short Wavelength Intersubband Transition in InGaAs/AlAs Quantum Wells
- Elevated Plasma Renin Activity in Aortitis Syndrome
- Exaggerated response of renin secretion to captopril (SQ 14225) in renovascular hypertension.
- Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
- Enhancement of Absorption Magnitude of Short-Wavelength Intersubband Transition in InGaAs/AlAs Quantum Wells
- Direct Fabrication of Photonic Crystal on Glass Substrate by Nanoimprint Lithography
- Near-infrared Intersubband Transitions in InGaAs/AlAs Quantum Wells on GaAs Substrate