KININ FORMATION BY CATHEPTIC ENZYME IN RAT STOMACH
スポンサーリンク
概要
- 論文の詳細を見る
Four uterine-contractile substances (a, b, c and d) were extracted from procedures with acetic acid, n-butanol, distilled water, and methanol from the reaction mixture obtained by incubating rat plasma kininogen with the kininforming enzyme in the rat stomach. Gradient and equilibrium chromatography on SP-Sephadex C-25 columns were carried out with the extract containing these materials (a, b, c and d). The materials could not be separated by chromatography on SP-Sephadex C-25, but were separated by high performance liquid chromatography (HPLC) with a Zorbax ODS reversed-phase column. All the materials (a, b, c and d) contracted the rat uterus and relaxed the rat duodenum. The uterine-contractile activity of the materials was abolished by chymotrypsin, but not by trypsin treatment. The retention times of materials a, c and d on HPLC were different from that of kallidin, MLBK, bradykinin (BK) and neurotensin; but the retention time of material b was equal to that of BK. The content ratio of a: b: c: d was 4: 4: 67: 25, calculated from the uterine-contractile activity of these materials. The apparent molecular weight of the major material c, estimated by gel chromatography, was 1650. Material c contracted the rat uterus (1.2×10<SUP>-10</SUP> g/ml), relaxed the rat duodenum (2×10<SUP>-10</SUP> g/ml), and produced a fall in rabbit blood pressure (4.4×10<SUP>-8</SUP> g/kg). Material c was classified as a biologically BK-like peptide which is distinct from kallidin, MLBK, BK and neurotensin.
- 社団法人 日本薬理学会の論文
著者
-
Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
-
Kobayashi Motoki
Department Of Bioengineering And Robotics Tohoku University
関連論文
- Inhibition of Anaphylactic Chemical Mediator Release by Tranilast.
- Antiallergic Effects of Mequitazine. II. : In Vivo Experiments.
- Antiallergic Effects of Mequitazine. I. : In Vitro Experiments.
- A Tiaramide Derivative, 5-Chloro-3-(4-hydroxypiperadinocarbonylmethyl) benzothiazoline-2-one (HPR-611), a Potent Inhibitor of Anaphylactic Chemical Mediator Release-A Distinctive Feature from Disodium Cromoglycate
- EFFECTS OF INTRAVENTRICULARLY ADMINISTERED SEROTONIN, NORADRENALINE, DOPAMINE AND METARAMINOL ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
- Characteristics of Methane Conversion under Combined Reactions of Solid Catalyst with Microwave Plasma
- PHARMACOLOGICAL ACTIVITIES OF A KININ RELEASED FROM RAT PLASMA BY CATHEPTIC ENZYME IN RAT STOMACH
- KININ FORMATION BY CATHEPTIC ENZYME IN RAT STOMACH
- A NEW BIOLOGICAL BRADYKININ-LIKE PEPTIDE IN RAT STOMACH
- EXISTENCE OF A BRADYKININ-LIKE SUBSTANCE, AND INFLUENCE OF CARBACHOL AND ATROPINE ON KININ-FORMING AND DESTROYING ACTIVITIES, AND KININ AND KININOGEN CONTENTS IN RAT STOMACH
- A BRADYKININ-LIKE SUBSTANCE IN RAT STOMACH
- STUDIES ON KININ-FORMING ENZYME IN RAT STOMACH
- PROPERTY OF KININ-FORMING ENZYME IN RAT STOMACH
- Proposal of New Nonvolatile Memory with Magnetic Nano-Dots
- Effect of AS-35 on Agonist-Induced Contractions and the Resting Tonus of Airway Smooth Muscles and the In Vitro Release of Chemical Mediators from Passively Sensitized Lung Fragments from Humans and Guinea Pigs.
- Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
- Effect of oxitropium bromide (Ba253) on increased airway resistance induced by various agonists and antigen in the guinea pig.
- Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells.
- Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
- Dimaprit, a Histamine H2-Agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release Is Restored by Thioperamide (H3-Antagonist), but Not by Cimetidine (H2-Antagonist).
- Significant Role of Peptide Leukotrienes (p-LTs) in the Antigen-Induced Contractions of Human and Guinea Pig Lung Parenchymas and Bronchi or Tracheas In Vitro.
- Two-Phase Increment of Ca2+ Uptake, Intracellular Ca2+ Concentration, and Histamine Release Following Antigen Stimulation in Mouse Bone Marrow-Derived Mast Cells (BMMC).
- Important Role of Peptide Leukotrienes (p-LTs) in the Resting Tonus of Isolated Human Bronchi.
- Effect of oexitropium bromide (Ba253) on isolated respiratory smooth muscle and release of chemical mediators from passively sensitized lung fragments.
- Studies on toluene diisocyanate (TDI)-induced delayed type hypersensitivity.
- Receptor binding profile of quinupramine, a new tricyclic antidepressant.
- Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.
- Binding characteristics of (3H)quinupramine to rat brain membrane fractions.
- MCI-826 Is a Potent and Selective Antagonist of Peptide Leukotrienes(p-LTs) and Has Characteristics Distinctive from Those of FPL 55712.