Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells.
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概要
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Anaphylactic histamine release from isolated rat peritoneal mast cells was concentration-dependently blocked by a 5-min treatment with exogenous histamine at 0.9 and 9 μM and enhanced by a 20- to 30-min treatment with thioperamide (H<SUB>3</SUB>-antagonist) at 3 μM with significance, but little affected by mepyramine (H<SUB>1</SUB>-antagonist) and cimetidine (H<SUB>2</SUB>-antagonist) at the cell concentration of 10<SUP>6</SUP> mast cells/ml. At a low concentration of mast cells (10<SUP>4</SUP> mast cells/ml), (<I>R</I>)-α-methylhistamine (α-MH), an H<SUB>3</SUB>-agonist, at 0.9-90 μM also inhibited the release in a concentration-dependent fashion. Thioperamide, but neither mepyramine nor cimetidine, significantly restored the decreased release by α-MH. However, the complete restoration by thioperamide could not be achieved because the drug itself slightly but concentration-dependently inhibited anaphylactic histamine release. On the other hand, not only betahistine and dimaprit but also α-MH did not suppress histamine release from the mast cells induced by compound 48/80. In rat plasma, considerable levels of histamine were detected. From these results, it is strongly suggested that histamine H</SUB>3</SUB>-like receptors are largely responsible for the negative feedback regulation of the anaphylactic histamine release from rat peritoneal mast cells.
- 公益社団法人 日本薬理学会の論文
著者
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Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Ogawa Kohji
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
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Nakao Shintaro
Department Of Mathematics Faculty Of Science Kanazawa University.
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Yamamura Hideki
Department Of Anatomy Hiroshima University School Of Medicine
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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