Receptor binding profile of quinupramine, a new tricyclic antidepressant.
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概要
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The receptor binding profile, composed of the K<SUB>i</SUB>-values measured in eight different receptor binding models using rat brain membranes, is reported for the new tricyclic antidepressant quinupramine, 10, 11-dihydro-5-(3-quinuclidinyl)-5<I>H</I>-dibenz[b, f]azepine, and three reference compounds with a tertiaryamine side chain. Quinupramine was found to possess high affinity for muscarinic cholinergic and histamine H<SUB>1</SUB> receptor binding sites in rat brain, whereas its affinity for imipramine binding sites was only one seventieth that of imipramine. Receptor binding profiles of the reference compounds were almost similar to that of quinupramine, except in the case of imipramine binding sites.
- 公益社団法人 日本薬理学会の論文
著者
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Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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SAKAMOTO Hirohiko
Department of Pharmacology, Kyoto Pharmaceutical University
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YOKOYAMA Nobuharu
Department of Pharmacology, Kyoto Pharmaceutical University
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