PHARMACOLOGICAL ACTIVITIES OF A KININ RELEASED FROM RAT PLASMA BY CATHEPTIC ENZYME IN RAT STOMACH
スポンサーリンク
概要
- 論文の詳細を見る
A kinin (material c), which was different from kallidin, methionyl-lysylbradykinin (MLBK), bradykinin (BK) and neurotensin, released from rat plasma by the kinin-forming enzyme in rat stomach was pharmacologically compared with BK and histamine or serotonin (5-HT) in various in vitro and in vivo systems. Material c produced contraction of isolated rat uterus, rat fundic strip, isolated guinea-pig ileum and guinea-pig tracheal chain; increased the vascular permeability of guinea-pig skin to circulating Evans blue; and produced a fall in rabbit blood pressure. Such effects were also produced by BK, but both were clearly discriminated by their quantitatively different activities. Histamine was not effective on isolated rat uterus, isolated rat duodenum, rat fundic strip, and rabbit blood pressure; produced contraction of isolated guinea-pig ileum and guinea-pig tracheal chain; and increased the vascular permeability of guinea-pig skin; but these activities were quantitatively different from those of material c. The contraction of isolated guinea-pig ileum elicited by histamine was sustained until it was removed from the bath, but those provoked by material c and BK gradually faded. 5-HT was qualitatively different from material c and BK with respect to contracting isolated rat duodenum. 5-HT also produced contraction of isolated rat uterus and rat fundic strip and produced a fall in rabbit blood pressure, but these activities were quantitatively different from those of material c and BK. As mentioned above, material c was quantitatively and qualitatively different from histamine and 5-HT.
- 社団法人 日本薬理学会の論文
著者
-
Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
-
Kobayashi Motoki
Department Of Bioengineering And Robotics Tohoku University
-
OHATA Katsuya
Department of Pharmacology, Kyoto College of Pharmacy
関連論文
- Inhibition of Anaphylactic Chemical Mediator Release by Tranilast.
- Antiallergic Effects of Mequitazine. II. : In Vivo Experiments.
- Antiallergic Effects of Mequitazine. I. : In Vitro Experiments.
- A Tiaramide Derivative, 5-Chloro-3-(4-hydroxypiperadinocarbonylmethyl) benzothiazoline-2-one (HPR-611), a Potent Inhibitor of Anaphylactic Chemical Mediator Release-A Distinctive Feature from Disodium Cromoglycate
- EFFECTS OF INTRAVENTRICULARLY ADMINISTERED SEROTONIN, NORADRENALINE, DOPAMINE AND METARAMINOL ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
- Characteristics of Methane Conversion under Combined Reactions of Solid Catalyst with Microwave Plasma
- PHARMACOLOGICAL ACTIVITIES OF A KININ RELEASED FROM RAT PLASMA BY CATHEPTIC ENZYME IN RAT STOMACH
- KININ FORMATION BY CATHEPTIC ENZYME IN RAT STOMACH
- A NEW BIOLOGICAL BRADYKININ-LIKE PEPTIDE IN RAT STOMACH
- EXISTENCE OF A BRADYKININ-LIKE SUBSTANCE, AND INFLUENCE OF CARBACHOL AND ATROPINE ON KININ-FORMING AND DESTROYING ACTIVITIES, AND KININ AND KININOGEN CONTENTS IN RAT STOMACH
- A BRADYKININ-LIKE SUBSTANCE IN RAT STOMACH
- STUDIES ON KININ-FORMING ENZYME IN RAT STOMACH
- PROPERTY OF KININ-FORMING ENZYME IN RAT STOMACH
- Proposal of New Nonvolatile Memory with Magnetic Nano-Dots
- Effect of AS-35 on Agonist-Induced Contractions and the Resting Tonus of Airway Smooth Muscles and the In Vitro Release of Chemical Mediators from Passively Sensitized Lung Fragments from Humans and Guinea Pigs.
- Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
- Effect of oxitropium bromide (Ba253) on increased airway resistance induced by various agonists and antigen in the guinea pig.
- Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells.
- Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
- Dimaprit, a Histamine H2-Agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release Is Restored by Thioperamide (H3-Antagonist), but Not by Cimetidine (H2-Antagonist).
- Significant Role of Peptide Leukotrienes (p-LTs) in the Antigen-Induced Contractions of Human and Guinea Pig Lung Parenchymas and Bronchi or Tracheas In Vitro.
- Two-Phase Increment of Ca2+ Uptake, Intracellular Ca2+ Concentration, and Histamine Release Following Antigen Stimulation in Mouse Bone Marrow-Derived Mast Cells (BMMC).
- Important Role of Peptide Leukotrienes (p-LTs) in the Resting Tonus of Isolated Human Bronchi.
- Effect of oexitropium bromide (Ba253) on isolated respiratory smooth muscle and release of chemical mediators from passively sensitized lung fragments.
- Studies on toluene diisocyanate (TDI)-induced delayed type hypersensitivity.
- Receptor binding profile of quinupramine, a new tricyclic antidepressant.
- Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.
- Binding characteristics of (3H)quinupramine to rat brain membrane fractions.
- MCI-826 Is a Potent and Selective Antagonist of Peptide Leukotrienes(p-LTs) and Has Characteristics Distinctive from Those of FPL 55712.