EFFECTS OF ROKITAMYCIN ON YOUNG RATS WITH HYPERBILIRUBINEMIA : DETERMINATION OF UNBOUND AND BRAIN BILIRUBIN LEVELS AND EXAMINATION FOR LOCALIZED YELLOW DISCOLORATION OF BRAIN TISSUE
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概要
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The effects of rokitamycin (RKM), a macrolide antibiotic, on young rats with hyperbilirubinemia were investigated. RKM at a dose of 1,000 mg/kg was orally administered to 14-day-old rats with hereditary, non-hemolytic hyperbilirubinemia (homozygous Gunn rats, total plasma bilirubin concentration : about 7 mg/dl). Animals given 10 ml/kg of 0.5% carboxymethyl cellulose (CMC) were used as control. Plasma total bilirubin concentration, plasma unbound bilirubin concentration and derebellar bilirubin level did not significantly change during 1, 3, 6 and 24 hours after administration of RKM or CMC. There was no significant difference in plasma total bilirubin concentration, plasma unbound bilirubin concentration and cerebllar bilirubin level between RKM-treated and control animals at 1, 3, 6 and 24 hours after the administration. No localized yellow discoloration of the brain tissue (non-cerebellar parts) was noted at 1, 3, 6 and 24 hours after administration of either RKM or CMC.
- 日本トキシコロジー学会の論文
- 1988-02-25
著者
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Yamauchi H
Istec Tokyo Jpn
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Yamauchi Hisao
Superconductivity Research Laboratory Istec:(present Address)research Laboratory Of Engineering Mate
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OHSUGI Mami
Department of Anatomy, Mie University School of Medicine
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Ohsugi Mami
Department Of Anatomy Mie University School Of Medicine
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Yamamoto H
The Research Institute For Iron Steel And Other Metals
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YAMAMURA Hideki
Department of Pharmacology, Kyoto Pharmaceutical University
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Yamauchi H
Institute For Materials Research Tohoku University:(present Office)neutron Science Research Center
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SAKURAI Sachiko
Department of Anatomy, Mie University School of Medicine
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KOBAYASHI Yoshiro
Toxicological Research Laboratories, Toyo Jozo Co., Ltd.
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SASAKI Masanori
Toxicological Research Laboratories, Toyo Jozo Co., Ltd.
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YAMAMOTO Hiroshi
Toxicological Research Laboratories, Toyo Jozo Co., Ltd.
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Yamamura H
Nagoya Univ. Nagoya Jpn
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Yamamoto H
Department Of Energy Engineering And Science Nagoya University
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Ohsugi M
Department Of Anatomy Mie University School Of Medicine
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Kobayashi Y
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Kobayashi Y
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Sasaki M
Banyu Pharmaceutical Co. Ltd. Saitama Jpn
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Yamamura Hideki
Department Of Anatomy Hiroshima University School Of Medicine
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Sakurai Sachiko
Department Of Anatomy Mie University School Of Medicine
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