EFFECTS OF ROKITAMYCIN ON BILIRUBIN-ALBUMIN BINDING : A STUDY IN VITRO

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概要

• 論文の詳細を見る

• The effects of rokitamycin, a macrolide antibiotic, on the binding of bilirubin to albumin were examined in vitro using blood plasma from young rats with hyperbilirubinemia, bilirubin-supplemented serum separated from human cord blood, and the human serum from a newborn infant with icterus gravis neonatorum. Rokitamycin at concentrations from 1 to 500μg/ml (the entire range over which experiments could be conducted) had little or no effect on the concentration of unbound bilirubin in any of the incubation mixtures used. This result suggests that rokitamycin has no effect on the binding of bilirubin to albumin.

• 日本トキシコロジー学会の論文
• 1993-08-25

著者

• Yamamura Hideki

  Research Institute Of Environment Medicine Nagoya University

• OHSUGI Mami

  Department of Anatomy, Mie University School of Medicine

• Ohsugi Mami

  Department Of Anatomy Mie University School Of Medicine

• KOBAYASHI Yoshiro

  Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry,

• SASAKI Masanori

  Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry,

• Yamamura H

  Nagoya Univ. Nagoya Jpn

• Ohsugi M

  Department Of Anatomy Mie University School Of Medicine

• Kobayashi Y

  Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko

• Yamamura Hideki

  Research & Development Department Biofermin Pharmaceutical Co. Ltd.

• Kobayashi Y

  Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University

• Sasaki M

  Banyu Pharmaceutical Co. Ltd. Saitama Jpn

• Sasaki Masanori

  Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd.

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