Effects of Bifidobacterium bifidum G9-1 on Hypercholesterolemic and Obese Diabetic Animal Models
スポンサーリンク
概要
- 論文の詳細を見る
Bifidobacterium bifidum G9-1 (BBG9-1) was administered orally to ExHC (Exogenously Hypercholesterolemic) rats, Wistar fatty rats and KK-Ay mice, and the effect on the lipids of the plasma and liver was found to be as follows. 1) BBG9-1 significantly reduced the levels of cholesterol and triglyceride in the plasma and liver of ExHC rats fed a cholesterol-enriched diet. In addition, the cholesterol level of low-density lipoprotein (LDL), and the cholesterol and triglyceride levels of very low-density lipoprotein/chylomicron (VLDL/CM) were lower in the BBG9-1-administered rats than in the control rats. 2) In Wistar fatty rats, BBG9-1 significantly decreased the levels of cholesterol and triglyceride in the liver but not those in the plasma. 3) In KK-Ay mice, BBG9-1 significantly reduced not only the levels of cholesterol and triglyceride in the plasma and liver, but also the plasma glucose level. These results suggest that BBG9-1 lowers elevated levels of blood lipids and/or hepatic lipids in hypertriglyceridemia, hypercholesterolemia and hyperglycemia.
- 日本ビフィズス菌センターの論文
- 2004-07-01
著者
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Yamamura Hideki
Research & Development Department Biofermin Pharmaceutical Co. Ltd.
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Ueda Takashi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Totani Nagao
Department Of Nutritional Physiology Faculty Of Nutrition Kobe Gakuin University
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OHNO Hiroshi
Research Institute, DAIICHI Pharmaceutical Co. Ltd.
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Ishihara Yoko
Research & Development Department Biofermin Pharmaceutical Co. Ltd.
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ARAI Teruhiko
Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
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Ohno H
Research & Development Department Biofermin Pharmaceutical Co. Ltd.
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Arai Teruhiko
Research & Development Department Biofermin Pharmaceutical Co. Ltd.
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Ueda Takashi
Department Of Biochemistry And Molecular Biology Kyoto Pharmaceutical University
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Ueda Takashi
Department Of Nutritional Physiology Faculty Of Nutrition Kobe Gakuin University
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Ohno Hiroshi
Research Institute Daiichi Pharmaceutical Co. Ltd.
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Ueda Takashi
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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Ohno Hiroshi
Research & Development Department Biofermin Pharmaceutical Co. Ltd.
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