Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis
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概要
- 論文の詳細を見る
Tranilast has long been used clinically to treat allergic diseases such as bronchial asthma. To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolonged survival of eosinophils at the concentration range of 30 μg/ml to 100 μg/ml. The DNA extracted from eosinophils cultured with tranilast showed signs of fragmentation that was comparable with apoptosis. Electron-microscopic analysis of activated eosinophils cultured with 100 μg/ml of tranilast also revealed morphologic features of apoptosis. These data suggest that tranilast may act in vivo on activated eosinophils to reduce inflammation in allergic diseases.
- 社団法人 日本薬理学会の論文
- 2001-05-01
著者
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Fukuda Takeshi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medici
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UEDA Takashi
Department of Surgery, National Hospital Organization Saga Hospital
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Ishii Y
Kyorin Univ. School Of Medicine Tokyo Jpn
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CHENG Gang
Department of Epidemiology, Shanghai Medical University
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Ishii Yoshiki
Department Of Pulmonary Medicine Jichi Medical School
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Eda Fukiko
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
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Eda Fukiko
Department Of Pulmonary Medical And Clinical Immunology Dokkyo University School Of Medicine
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Eda Fukiko
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Nakajima Hiromichi
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division Sumitomo M
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Ishii Yoshiki
Department Of Biology Faculty Of Science Kobe University
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Fukuda Takeshi
Department Of Applied Chemistry And Biotechnology Graduate School Of Engineering University Of Fukui
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Cheng Gang
Department Of Epidemiology Shanghai Medical University
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KINJYO Syunichi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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NAKAJIMA Hirokazu
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Kinjyo Syunichi
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Nakajima Hirokazu
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Cheng Gang
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Ueda Takashi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Nakajima Hirokazu
Department Of Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Ueda Takashi
Department Of Biochemistry And Molecular Biology Kyoto Pharmaceutical University
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Fukuda Takeshi
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Ueda Takashi
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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Ueda Takashi
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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