Riluzole-induced Lung Injury in Two Patients with Amyotrophic Lateral Sclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Riluzole has recently been proven as the first effective drug for the treatment of amyotrophic lateral sclerosis (ALS). We report two rare cases of lung injury caused by riluzole therapy in patients with ALS. Chest radiographs showed bilateral lower lobe, dorsal-dominant ground glass opacity, and/or consolidation. A drug lymphocyte stimulation test (DLST) of peripheral blood or bronchoalveolar lavage cells was positive for riluzole. Histopathological examination of lung biopsy specimens revealed lung injury without fungoid granuloma, vasculitis, or diffuse alveolar damage. To the best of our knowledge, this is the first report of riluzole-induced lung injury with positive DLST results.
著者
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Fukushima Fumiya
Department Of Internal Medicine Shioya General Hospital
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Sugiyama Kumiya
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Hirata Hirokuni
Department Of Pulmonary Medical And Clinical Immunology Dokkyo University School Of Medicine
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Tatewaki Masamitsu
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University
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Fukushima Yasutsugu
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University
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Fukuda Takeshi
Department Of Applied Chemistry And Biotechnology Graduate School Of Engineering University Of Fukui
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Arima Masafumi
Department Of Developmental Genetics (h2) Graduate School Of Medicine Chiba University
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Chibana Kazuyuki
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Shiobara Taichi
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Watanabe Mineaki
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine
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Koichi Honma
Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University, Japan
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Chibana Kazuyuki
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Kakuta Takuya
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Soda Sayo
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Fukushima Fumiya
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Sugiyama Kumiya
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Fukushima Yasutsugu
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Kakuta Takuya
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology
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Tatewaki Masamitsu
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Hirata Hirokuni
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Shiobara Taichi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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Fukuda Takeshi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan
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