CD4^+ -Central Memory and Effector Memory T Cells in Patients with Asthma
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概要
- 論文の詳細を見る
Asthma is associated with chronic airway inflammation, suggesting that its pathogenesis is driven by type 2 helper T (Th2) cells among memory/effector CD4^+ T, cells. CCR4, a chemokine receptor, is considered a preferential marker for Th2 cells. Another chemokine receptor, CCR7, is regarded to be a suitable molecule for T-cell homing to lymph nodes. Recent studies have demonstrated that memory T cells are subdivided into central memory T cells (TCMs) and effector memory T cell (TEMs), designated as CCR7^+ CD62L^+ CD45RA^- and CCR7^- CD62L^- CD45RA^-, respectively. Nevertheless, the properties of TCMs and TEMs in allergic diseases remains unknown. This study focused on the cytokine production and the populations and survival of CD4^+ TCMs and CD4^+ TEMs in patients with asthma (n=3-5), as compared with those in healthy controls (n=4-5). We found that the population of TEMs in asthma was greater than that in healthy control. IL-4-producing cells among both activated TCMs and TEMs and IFN-γ-producing cells among TEMs were more abundant in asthma than in healthy control. Apoptotic cells stained with annexin V and propidium iodide (PI) were more numerous among both TCMs and TEMs in asthma than in healthy control after stimulation with both phorbol myristate acetate and ionomycin. Although CCR4^+ cell populations among TCMs and TEMs were similar in patients with asthma and healthy controls, cytokine-production profiles differed significantly. Namely, CCR4^+ (but not CCR4^-) TCMs and TEMs produced IL-4 and CCR4^+(but not CCR4^-) TCMs produced IFN-γ in both asthma and healthy control. In contrast, both CCR4^+ and CCR4^- TEMs produced IFN-γ. The production levels of IL-4 and IFN-γ by each subpopulation were greater in asthma than in healthy control. Our results suggest that increased CCR4^+-TEMs in peripheral blood accumulate in the lung and to play an important role in the development and maintenance of airway inflammation in asthma. To our knowledge, this is the first study to investigate CCR4^+ TCMs and TEMs in bronchial asthma and healthy controls.
- 獨協医科大学の論文
- 2006-03-25
著者
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HONDA Kyoko
Department of Microbiology, Institute of Basic Medical Sciences
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Honda Kyoko
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Yamaguchi Bunpei
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Hirata Hirokuni
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Yukawa Tatsuo
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Arima Masafumi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Hirata Hirokuni
Department Of Pulmonary Medical And Clinical Immunology Dokkyo University School Of Medicine
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Hirata Hirokuni
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Yukawa Tatsuo
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Yukawa Tatsuo
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University School Of Medicin
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Arima Masafumi
Department Of Developmental Genetics (h2) Graduate School Of Medicine Chiba University
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Arima Masafumi
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine:depart
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Honda Kyoko
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Yamaguchi Bunpei
Department Of Pulmonary Medical And Clinical Immunology Dokkyo University School Of Medicine
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Yamaguchi Bunpei
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Hirata Hiroyuki
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Tochigi, Japan
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Honda Kyoko
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
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Hirata Hirokuni
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine
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