Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma
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概要
- 論文の詳細を見る
Mast cells play important roles in both acute-and late-phase allergic reactions mediated by IgE, such as those in bronchial asthma. Remodeling of the airway wall may contribute to the development of chronic refractory asthma; effective treatment for remodeling is currently lacking. Tryptase released by degranulated mast cells may participate in airway remodeling by stimulating the proliferation of airway smooth-muscle cells and fibroblasts and promoting the production of extracellular matrix. We found that continued antigen challenge produced time-dependent increases in the number of goblet cells, which are essential for sputum production, as well as the number of mast cells. Furthermore, the expression of amphiregulin released from mast cells was up-regulated by after ovalbumin challenges in mice. The number of amphiregulin-positive cells positively correlated with the degree of goblet-cell hyperplasia. Our results suggest that mast cells also play a key role in airway remodeling.
- 獨協医科大学の論文
- 2006-03-25
著者
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MASUDA Hiroyuki
Department of Neurosurgery, Toho University, Omori Medical Center
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Sagara Hironori
獨協医科大学 医学部内科学(呼吸器･アレルギー)
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Sagara Hironori
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University School Of Medicin
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Manaka Takako
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Toda Masao
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Sugiyama Kumiya
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
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Sugiyama Kumiya
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Toda Masao
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Manaka Takako
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Masuda Hiroyuki
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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Masuda Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Sagara Hironori
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo University School Of Medicine
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