Visible Light-Sensitized Oxidation of Arachidonic Acid in the Presence of Inperatorin.
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概要
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To understand the mechanism of the phototoxic effects of inperatorin, a psoralen derivative used as a pigmentation agent, we have investigated the photosensitized oxidation of arachidonic acid (ARA) by irradiation with visible light (>400nm) in the presence of inperatorin. HPLC and GC/MS analyses of the products showed the formation of many hydroperoxyeicosatetraenoic acids (HPETEs) including the prod-ucts of lipoxygenase-catalyzed reactions such as 5- and 15-HPETEs, which are the precursors of chemical mediators such as leukotrienes and lipoxins, during the reaction. Active oxygen scavenging agents such as D-mannitol, superoxide dismutase, and β-carotene inhibited the formation of the oxidation products, indicating that the oxidation reaction was mediated by various active oxygen species. These results suggest that the phototoxic effects of inperatorin could also be induced by visible light and could be explained at least partially in terms of inflammation initiated by the biologically active HPETEs arising from photosensitized oxygenation reactions of ARA with the drug.
- 財団法人 学会誌刊行センターの論文
著者
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HIROTA Rie
Department of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University
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Hirota Rie
Department Of Nutritional Physiology Faculty Of Nutrition Kobe Gakuin University
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Morita Mayumi
Department Of Food Science And Nutrition Teikoku Women's University
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Fukui Yuka
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Ueda Takashi
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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UEDA Takashi
Department of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University
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NAKAYAMA Toru
Department of Applied Microbial Technology, The Kumamoto Institute of Technology:(Present office)Institute for Fundamental Research, Suntory Ltd.
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OSAKADA Kazuko
Department of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University
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MATSUOKA Masakazu
Department of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University
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IIZUMI Hisako
Department of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University
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