Chemical Pleurodesis Could Exacerbate Lymphedema of Yellow Nail Syndrome

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Chemical pleurodesis is sometimes performed for the management of intractable pleural effusion. We describe a woman with yellow nail syndrome (YNS), which is characterized by yellow discoloration of the nails, lymphedema, and pleural effusion. At the age of 43, she was hospitalized with edema of the lower limbs. Despite a number of medical treatments, massive lymphedema of lower limbs developed over a period of three years, resulting in skin cracks and subsequent infection, septicemia and multiple organ failure. At autopsy, abnormally dilated lymph and blood vessels were evident in soft tissue throughout the whole body. She had undergone chemical pleurodesis at 36 years of age for reduction of pleural effusion associated with YNS. Our case illustrates possible complication of chemical pleurodesis to YNS, which resulted in accumulation of lymph flow into the lower half of the body.
長崎大学の論文