Evidence for the Excitatory Cholinergic Innervation in the Rabbit Portal Vein.
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概要
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We examined the possible existence of excitatory cholinergic innervation in isolated rabbit portal vein. Longitudinal strips of the vein in the presence of both phenoxybenzamine, an α-adrenoceptor antagonist, and <I>N<SUP>G</SUP></I>-nitro-L-arginine, an inhibitor of nitric oxide synthase, exhibited a small contraction in response to transmural electrical stimulation (ES). The contractile response to ES was augmented by physostigmine, an anticholinesterase agent, and inhibited by atropine. These findings indicate the existence of an excitatory cholinergic innervation in addition to the known adrenergic and non-adrenergic, non-cholinergic innervations in the rabbit portal vein.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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Shigei Tatsuro
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
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Mutsukado Yasushi
Department of Pharmacology, Hiroshima University School of Medicine
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