A regional difference in endothelium-dependent relaxation responses to acetylcholine in the canine venous system.
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概要
- 論文の詳細を見る
Endothelium-dependent relaxations of canine veins isolated from 15 different sites were examined. Acetylcholine (ACh, 10<SUP>-10</SUP>-10<SUP>-6</SUP>M) caused marked endothelium-dependent relaxations in the external jugular vein, superior vena cava, brachiocephalic vein, segment A (supradiaphragmatic portion) and D (infrarenal portion) of the inferior vena cava. However, only contractile responses were induced by ACh in the portal, mesenteric veins and the segment C of the inferior vena cava (between liver and renal veins) with or without endothelium. The other 7 veins showed only small endothelium-dependent relaxations (10-20%). These results indicated that the endothelium-dependent responses of canine veins to ACh are regionally different.
- 公益社団法人 日本薬理学会の論文
著者
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Furuta Tatsuji
Department Of Cardiology Anjo Kosei Hospital
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Shigei Tatsuro
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
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FURUTA Tatsuji
Department of Pharmacology, Nagoya University School of Medicine
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