POSSIBLE EMBRYOGENETICAL DIFFERENCES OF THE DOG VENOUS SYSTEM IN SENSITIVITY TO VASOACTIVE SUBSTANCES
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概要
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Using isolated dog veins, we examined whether correlations exist between the regional differences in sensitivity to drugs and their embryogenesis. Twelve different veins were dissected. In the analysis, the data obtained previously for the inferior vena cava were also included. Spiral strips were prepared and the contractile responses to cumulative application of norepinephrine (NE), 5-hydroxytryptamine (5-HT), histamine (Hist) and acetylcholine (ACh) were recorded isometrically. For each drug, a histogram was drawn by stacking the overlapping ranges (mean±S.E.) of the pD<SUB>2</SUB> value for each vein. The histogram indicated the number of veins which could share the same pD<SUB>2</SUB> value. We obtained the following results: (I) Veins of the body wall had high sensitivity to NE (pD<SUB>2</SUB> >6.40) and 5-FIT (pD<SUB>2</SUB> >6.60) and veins of the intestinal system, except for the splenic vein, were not so sensitive to NE and 5-HT, but exhibited high sensitivity to Hist (pD<SUB>2</SUB> >4.60), (2) the middle segment of inferior vena cava responded similarly to portal and mesenteric veins; (3) the responses of splenic vein to the agents used were quite different from those of portal and mesenteric veins. These results suggest possible correlations between the responsiveness of venous smooth muscles and embryogenesis of the venous system.
- 社団法人 日本薬理学会の論文
著者
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SHIGEI Tatsuro
Department of Pharmacology, Nagoya University School of Medicine
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Ishikawa Naohisa
Department Of Pharmacology Aichi Medical University School Of Medicine
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ICHIKAWA Tomohiro
The Second Department of Internal Medicine, Nagoya University School of Medicine
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Shigei Tatsuro
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
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