S1-receptor participation in serotonin-induced pulmonary edema in the dog.
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概要
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A canine lung-perfusion preparation was used to evaluate the role of serotonin receptor subtype in the development of serotonin-induced pulmonary edema. Ketanserin, an S<SUB>2</SUB>-receptor antagonist, blocked an increase in pulmonary arterial pressure caused by serotonin, but not the development of pulmonary edema. Methysergide, an S<SUB>1</SUB>- and S<SUB>2</SUB>-receptor antagonist, prevented the increase in pulmonary arterial pressure and edema formation caused by serotonin. These results suggest that the S<SUB>1</SUB>-receptor may participate in the development of pulmonary edema.
- 公益社団法人 日本薬理学会の論文
著者
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Ishikawa Naohisa
Department Of Pharmacology Aichi Medical University School Of Medicine
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Kamiya Isao
Department of Chemistry, College of General Education, Nagoya University
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SUMITA Toshiaki
Department of Pharmacology, Nagoya University School of Medicine
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