An extension of pA principle to the potentiation of drug effects, and its application to the biological assay of some anticholinesterases and cardenolides.
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概要
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A new scale for the potentiation was introduced and was termed pA<SUB>1/2</SUB>. The value can be calculated by using an equation ; pA<SUB>1/2</SUB>=pAx + log (1/x-1), which is similar to that which is used for the calculation of pA<SUB>2</SUB>. For the use of the equation, the parallel shift of the dose-response curve and the unchanged maximum response are prerequisites. This experiment showed the validity and the usefulness of calculating the pA<SUB>1/2</SUB> values, in the biological assay. In the assay of anticholinesterases, the potentiating effects of neostigmine or physostigmine on the acetylcholine-induced contraction were examined, by using frog's rectus abdominis. The pA<SUB>1/2</SUB> values obtained in the presence of two different concentrations of anticholinesterases were the same, indicating that pA<SUB>1/2</SUB> is a parameter which is specific to the potentiator. The potentiating effects of some cardenolides on the K-induced contracture were examined, by using the frog's ventricular muscles. The relative potencies of four cardenolides obtained from the pA<SUB>1/2</SUB> values well agreed with those reported earlier. The amount of the cardenolides required for this assay was smaller than required for other methods.
- 公益社団法人 日本薬理学会の論文
著者
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SHIGEI Tatsuro
Department of Pharmacology, Nagoya University School of Medicine
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ICHIKAWA Tomohiro
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceu
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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Ishikawa Naohisa
Department Of Pharmacology Aichi Medical University School Of Medicine
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Shigei Tatsuro
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
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